“喝酒脸红”基因探秘——遗传学实验案例深度挖掘与应用探讨

doi:10.16288/j.yczz.25-002

遗传 ›› 2025, Vol. 47 ›› Issue (10): 1169-1175.doi: 10.16288/j.yczz.25-002

• 遗传学教学 • 上一篇

“喝酒脸红”基因探秘——遗传学实验案例深度挖掘与应用探讨

赵雪莹¹^,²(), 李有², 卢大儒², 皮妍¹^,²()

1.复旦大学，生物科学国家级实验教学示范中心，上海 200433
2.复旦大学生命科学学院，上海 200433

收稿日期:2025-01-02 修回日期:2025-01-17 出版日期:2025-10-20 发布日期:2025-04-18
通讯作者: 皮妍，博士，教授，研究方向：分子遗传学。E-mail: yanpi@fudan.edu.cn
作者简介:赵雪莹，博士，实验师，研究方向：分子遗传学。E-mail: xueying_zhao@fudan.edu.cn
基金资助:
2022年度上海高校市级重点课程建设项目(19);复旦大学2023年度课程思政教育教学改革研究课题-遗传学实验(IAH6222054/096)

Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases

Xueying Zhao¹^,²(), You Li², Daru Lu², Yan Pi¹^,²()

1. National Demonstration Center for Experimental Biology Education, Fudan University, Shanghai 200433, China
2. School of Life Sciences, Fudan University, Shanghai 200433, China

Received:2025-01-02 Revised:2025-01-17 Published:2025-10-20 Online:2025-04-18
Supported by:
2022 Shanghai Municipal-level Key Courses Construction Project for Higher Education Institutions(19);2023 Fudan University Curriculum Ideological and Political Education Teaching Reform Research Project-Genetics Experiment(IAH6222054/096)

摘要/Abstract

摘要：

遗传学相关技术已越来越深入影响着人类的健康与生活。从理论到实践，以学科应用的典型案例开展教学，是近年来遗传学教学领域较为热衷的新模式。本文以生活中“喝酒脸红”表型为例，将表型分析、群体分析和家系分析等多角度、多层面的遗传学理论知识与实践案例有机融合，在激发学生主动学习兴趣的同时，系统培养学生理论联系实际，从实践中发现问题、解决问题的能力，并在实践中进一步拓展学习基因检测相关的生命伦理、基因信息保护、遗传资源保护等知识，激发学生主动思考，以期达到全面培养学生的科学思维能力与科学素养的目的。

关键词: ADH1B基因, ALDH2基因, 遗传学实验教学, 生命伦理

Abstract:

Genetic related technologies are increasingly influencing human health and life. From theory to practice, teaching through typical cases of disciplinary applications has become a popular new model in the field of genetics education. This experiment takes the phenotype case of “alcohol flush” as an example, organically integrating genetic knowledge from multiple perspectives and levels such as phenotypic analysis, population genetic analysis and pedigree analysis with experimental cases. In teaching practice, the “alcohol flush” case study can greatly stimulate students’ interest in active learning, cultivate students’ ability to connect theory with practice, discover and solve problems from practice, and further expand their learning of genetic testing related bioethics, genetic information protection, genetic resource protection, and other knowledge through personal practical teaching, thus cultivate students’ scientific thinking ability and scientific literacy.

Key words: ADH1B, ALDH2, genetic experiment, bioethics

赵雪莹, 李有, 卢大儒, 皮妍. “喝酒脸红”基因探秘——遗传学实验案例深度挖掘与应用探讨[J]. 遗传, 2025, 47(10): 1169-1175.

Xueying Zhao, You Li, Daru Lu, Yan Pi. Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases[J]. Hereditas(Beijing), 2025, 47(10): 1169-1175.

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“喝酒脸红”基因探秘——遗传学实验案例深度挖掘与应用探讨

Exploring the gene of “alcohol flush”——in-depth exploration and application of genetic experimental cases

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