遗传 ›› 2002, Vol. 24 ›› Issue (3): 305-309.

• 论文 • 上一篇    下一篇

三氧化二砷(As2O3)对蚕豆根尖毒性效应的细胞遗传学研究

钱晓薇1;朱小春2;陈哲晓1;林柳琴1 QIAN Xiao-wei1;ZHU Xiao-chun2;CHEN Zhe-xiao1;LIN Liu-qin1   

  1. 1.温州师范学院生物与环境科学系,浙江 温州 325003; 2.温州医学院附属第一医院,浙江 温州 325000 1.Department of Biology and Enviromental Science,Wenzhou Normal College,Wenzhou 325003,China; 2.The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000,China
  • 收稿日期:1900-01-01 出版日期:2002-06-10 发布日期:2002-06-10

Studies of Cytogenetic Toxic Effect of As2O3 on Vicia Faba Root Tip Cells in Vivo

  • Received:1900-01-01 Online:2002-06-10 Published:2002-06-10

摘要: 本文以蚕豆根尖为材料,研究不同浓度As2O3在不同的处理时间内对蚕豆胚根根尖的细胞遗传学毒性效应。结果表明:不同浓度的As2O3在不同处理时间内均能诱发较高的微核率和染色体畸变率,并能有效地积累中期分裂相,阻止其进入后期与末期。结论是As2O3对蚕豆根尖细胞具有明显的细胞遗传学毒性效应,并具有积累有丝分裂中期细胞的效应。
Abstract:The cytogenetic toxic effects of different concentration of As2O3 within different time on the cell of Vicia Faba root tip were studied.The results indicate that the different concentrations of As2O3 can induce high frequency of micronucleus and chromosome aberration.Besides,it can accumulate the metaphases in mitosis efficiently and prevent the cells from continuing their cell cycle.It shows that As2O3 has marked cytogenetic toxic effect on the root tip cells of Vicia Faba,and effect of accumulating the metaphases in mitosis.

关键词: As2O3, 遗传学毒性, arsenic trioxide, 染色体畸变率
Key words,
微核率