肌动蛋白细胞骨架在小鼠第二生心区祖细胞部署发育中的作用

doi:10.16288/j.yczz.18-293

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (2): 125-136.doi: 10.16288/j.yczz.18-293

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The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells

Zhongying Liu,Xia Huang,Ziyi Li,Zihao Yang,Baiyin Yuan()

College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China

Received:2018-10-29 Revised:2019-01-18 Online:2019-02-20 Published:2019-01-29
Supported by:
[Supported by the National Natural Science Foundation of China ](31701266)

Abstract

Abstract:

The vertebrate heart tube originates from cardiogenic mesodermal cells in the early embryo, and subsequently elongates by progressive addition of second heart field (SHF) progenitor cells from adjacent pharyngeal mesoderm and splanchnic mesoderm. Insufficient addition of SHF cells to the heart tube causes the failure of maximal elongation of the heart tube, which results in a series of developmental defects including the most common congenital birth defects, such as right ventricular dysplasia and outflow tract septation, and alignment anomalies. SHF cells form an atypical, apicobasally polarized epithelium which is characterized by apical monocilia, and dynamic actin-rich basal filopodia. In this review, we summarize recent research progresses of actin cytoskeleton in the deployment process of mouse SHF progenitor cells, and reveal the significance of actin cytoskeleton in SHF development, especially in the deployment of SHF cells to the outflow tract, to provide theoretical reference for elucidating and understanding the biological characteristics of SHF deployment.

Key words: actin, second heart field, cell deployment, mouse

Zhongying Liu,Xia Huang,Ziyi Li,Zihao Yang,Baiyin Yuan. The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells[J]. Hereditas(Beijing), 2019, 41(2): 125-136.

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