FSCN1在乳腺癌发生发展中的作用及其调控机制

doi:10.16288/j.yczz.22-346

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (2): 115-127.doi: 10.16288/j.yczz.22-346

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The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression

Dong Chang¹(), Xiangxiang Liu¹, Rui Liu², Jianwei Sun¹()

1. Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650504, China
2. Department of Breast Surgery, Third Affiliated Hospital, Kunming Medical University, Kunming 650118, China

Received:2022-11-01 Revised:2022-12-27 Online:2023-02-20 Published:2022-12-28
Contact: Sun Jianwei E-mail:13648831440@139.com;jwsun@ynu.edu.cn
Supported by:
the National Natural Science Foundation of China(82273460);the National Natural Science Foundation of China(32260167);the Applied Basic Research Foundation of Yunnan Province(202101AV070002);the Applied Basic Research Foundation of Yunnan Province(2019FY003030);the Major Science and Technique Programs in Yunnan Province(202102AA310055);the Graduate Scientific Research Innovation Project of Yunnan University(ZC-22223017);the Graduate Scientific Research Innovation Project of Yunnan University(KC-22222424);the NHC Key Laboratory of Drug Addiction Medicine(2020DAMPO-005)

Abstract

Abstract:

FSCN1, an actin-bundling protein, is highly expressed in almost all metastatic tumors and is associated with the poor prognosis. In breast cancer FSCN1 is highly expressed in basal-like and triple negative subgroups. There is significant progress in understanding the role of fascin in breast cancer. Studies on FSCN1 in recent years have revealed that FSCN1 not only promotes tumor migration, invasion, metastic colonization, cancer cell self-renewal and drug resistance, but also regulates glucose and lipid metabolism and mitochondrial remodeling in tumor cells. In this review, we focus on the structure and regulatory mechanism of FSCN1 in breast tumorigenesis and metastasis, and discuss the clinical value of FSCN1 with the aim to provide a direction for further research in this field.

Key words: FSCN1, actin bundle, breast cancer, tumorigenesis, tumor progression

Dong Chang, Xiangxiang Liu, Rui Liu, Jianwei Sun. The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression[J]. Hereditas(Beijing), 2023, 45(2): 115-127.

Figures/Tables 4

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序号	样本	方法	临床价值	参考文献
1	组织	IHC	预测不良预后和病情进展	[29]
2	组织	IHC	FSCN1与其他因素(MAP17、GATA3等)联合检测可作为预后不良的标志物	[30,82,83]
3	组织	IHC	FSCN1本身就具有诊断标记物的价值(TNBC和其他类型)	[26,28,30,84]
4	血液	SNP基因分型分析	FSCN1基因变异与乳腺癌的高危相关	[24]

序号	名称	来源	作用机制	参考文献
1	米格拉他汀类似物	链霉菌或人工合成	占据FSCN1的肌动蛋白结合部位	[16,20,85,86]
2	LAP3抑制剂	天然海产品	间接下调FSCN1的表达	[47]
3	沙枣提取物	沙枣	减少HER2阳性乳腺癌细胞中FSCN1的表达	[57]
4	岛霉素C	白链霉菌	间接介导FSCN1的下调	[43]
5	四氢嘧啶类化合物	人工合成	与FSCN1的活性部位结合	[87]
6	DHA	体内转化或食物来源	间接下调FSCN1的表达	[55]
7	Crispene E	波叶青牛胆	间接介导FSCN1的下调	[42]
8	噻唑类化合物	人工合成	与FSCN1互作以抑制其活性	[88]
9	葡萄籽提取物	葡萄籽	间接下调FSCN1的表达	[89]

The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression

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