Rab蛋白家族在神经类疾病中的作用

doi:10.16288/j.yczz.20-318

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (1): 16-29.doi: 10.16288/j.yczz.20-318

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The roles of Rab protein family in neurological diseases

Anping Wu, Hong Qing, Zhenzhen Quan()

Key Laboratory of Molecular Medicine and Biotherapy,School of Life Science, Beijing Institute of Technology, Beijing 100081, China

Received:2020-11-17 Revised:2021-01-06 Online:2021-01-20 Published:2021-01-12
Contact: Quan Zhenzhen E-mail:qzzbit2015@bit.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China No(81701260)

Abstract

Abstract:

The intracellular membrane trafficking is a complicated pathway network. Rab GTPases are key regulators of membrane trafficking that are generally considered as specific markers and indicators of various organelles and membrane trafficking in endocytic and secretory pathways. Dysfunction in axonal and endosomal transport related to Rab proteins is one of the most important causes of neurodegenerative diseases. In this review, we mainly introduce how the Rab proteins change in different neurodegenerative diseases and their regulatory roles in the pathological mechanisms of related diseases. We also discuss the relationships between mitochondrial and glial cell dysfunctions and Rab proteins. Further exploration of the regulatory roles of Rab proteins will shed lights on revealing the pathogenic mechanisms of neurological diseases and providing potential targets for the early diagnosis and treatment of neurological diseases.

Key words: Rab proteins, neurological diseases, membrane trafficking, mitochondria, astrocytes

Anping Wu, Hong Qing, Zhenzhen Quan. The roles of Rab protein family in neurological diseases[J]. Hereditas(Beijing), 2021, 43(1): 16-29.

Figures/Tables 3

Fig. 1

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Table 1

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名称	功能	影响的神经退行性疾病
Rab 1A	调节从内质网(ER)到高尔基体室以及细胞表面的囊泡蛋白运输	AD、PD
Rab 3	参与胞吐作用,在神经递质释放和突触可塑性中起关键作用	AD、PD
Rab 5	介导货物从质膜到早期内含体的运输并充当早期内含体的标记物,在内含体运输中、突触和突触功能中起重要作用	AD、ALS、HD
Rab 7	调节货物从早期到晚期内含体的运输并充当晚期内含体的标记;控制神经营养蛋白受体的逆行轴突运输	AD、PD 、ALS 、CMT2B
Rab 8	是极化运输的重要调节剂,并参与反高尔基网络至基底外侧质的膜运输,突起形成和纤毛发生	AD、PD 、HD
Rab 10	调节小泡运输,参与反高尔基网络、内质网到基底膜的组织	AD、PD
Rab 11	与再循环内含体有关,控制着反高尔基网络与内吞在循环室或质膜之间的物质运输	AD、PD 、ALS 、HD
Rab 13	与生物合成和内含体再循环途径有关	PD
Rab 21	在内吞和自噬中发挥作用	AD
Rab 29	与溶酶体相关细胞器生物发生相关	PD
Rab 31	在表皮生长因子受体转运至晚期内含体的运输中发挥作用	与星形胶质细胞相关
Rab 35	控制货物从早期内含体、循环内含体直接返回质膜的快速回收	PD、线粒体相关

The roles of Rab protein family in neurological diseases

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