TET蛋白的去甲基化机制及其在调控小鼠发育过程中的作用

doi:10.16288/j.yczz.2015.01.005

[an error occurred while processing this directive]

HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (1): 34-40.doi: 10.16288/j.yczz.2015.01.005

• Reviews • Previous Articles Next Articles

Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development

Zhenwei Jia, Shuxin Gao, Yongchun Zhang, Xianhua Zhang

Institute of Yellow Cattle Genetics-Breeding and Reproduction, College of Animal Science and Technology, Inner Mongolia University for the Nationalities, Tongliao 028000, China

Received:2014-04-08 Revised:2014-09-20 Online:2015-01-20 Published:2015-01-20

Abstract

Abstract: TET (ten-eleven translocation) protein family includes three members TET1, TET2 and TET3, which belong to alpha-ketoglutaric acid ( α-KG )- and Fe²⁺-dependent dioxygenase superfamily, and have the capacity to convert 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC), 5-formylcytosine (5 fC) and 5-carboxylcytosine (5 caC). At present, growing lines of evidence indicate that TET proteins are involved in the control of active or passive DNA demethylation via different mechanisms; moreover, their activities may be regulated by some cellular factors. TET proteins play vital roles in modulating mammal development, including primordial germ cell formation, embryonic development, stem cells pluripotency, nerve and brain development, etc. The identification of biological roles of TET proteins will open a new field in epigenetic research, and these studies on TET proteins are of great significance to life science research. Here, we review TET proteins from their structure, molecular mechanisms of DNA demethylation and function in the regulation of mouse development, which may provide the basis for understanding the functions of TET proteins.

Key words: TET proteins, demethylation, epigenetics, mouse development

Zhenwei Jia, Shuxin Gao, Yongchun Zhang, Xianhua Zhang. Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development[J]. HEREDITAS(Beijing), 2015, 37(1): 34-40.

References

[1] Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science , 2009, 324(5929): 930-935.
[2] Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science , 2011, 333(6047): 1300-1303.
[3] Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y. Role of Tet proteins in 5 mC to 5 hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature , 2010, 466(7310): 1129-1133.
[4] Ficz G, Branco MR, Seisenberger S, Santos F, Krueger F, Hore TA, Marques CJ, Andrews S, Reik W. Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation. Nature , 2011, 473(7347): 398-402.
[5] Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao XY, Perna F, Pandey S, Madzo J, Song CX, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell , 2011, 20(1): 11-24.
[6] Wu H, D'Alessio AC, Ito S, Xia K, Wang ZB, Cui KR, Zhao KJ, Sun YE, Zhang Y. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature , 2011, 473(7347): 389-393.
[7] Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, Zhang K, Zhang Y. Tet1 controls meiosis by regulating meiotic gene expression. Nature , 2012, 492(7429): 443- 447.
[8] Xu YF, Wu FZ, Tan L, Kong LC, Xiong LJ, Deng J, Barbera AJ, Zheng LJ, Zhang HK, Huang S, Min JR, Nicholson T, Chen TP, Xu GL, Shi Y, Zhang K, Shi YG. Genome-wide regulation of 5 hmC, 5 mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell , 2011, 42(4): 451-464.
[9] Xu YF, Xu C, Kato A, Tempel W, Abreu JG, Bian CB, Hu YG, Hu D, Zhao B, Cerovina T, Diao JB, Wu FZ, He HH, Cui QC, Clark E, Ma C, Barbara A, Veenstra GJC, Xu GL, Kaiser UB, Liu XS, Sugrue SP, He X, Min JR, Kato Y, Shi YG. Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell , 2012, 151(6): 1200-1213.
[10] Ko M, An J, Bandukwala HS, Chavez L, Äijö T, Pastor WA, Segal MF, Li HM, Koh KP, Lähdesmäki H, Hogan PG, Aravind L, Rao A. Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX. Nature , 2013, 497(7447): 122-126.
[11] Guo JU, Su YJ, Zhong C, Ming GL, Song HJ. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell , 2011, 145(3): 423-434.
[12] He YF, Li BZ, Li Z, Liu P, Wang Y, Tang QY, Ding JP, Jia YY, Chen ZC, Li L, Sun Y, Li XX, Dai Q, Song CX, Zhang KL, He C, Xu GL. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science , 2011, 333(6047): 1303-1307.
[13] Zhang L, Lu XY, Lu JY, Liang HH, Dai Q, Xu GL, Luo C, Jiang HL, He C. Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol , 2012, 8(4): 328-330.
[14] Valinluck V, Tsai HH, Rogstad DK, Burdzy A, Bird A, Sowers LC. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res , 2004, 32(14): 4100-4108.
[15] Valinluck V, Sowers LC. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res , 2007, 67(3): 946-950.
[16] Inoue A, Zhang Y. Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science , 2011, 334(6053): 194.
[17] Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ,

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Tianyi Wang, Yingxiang Wang, Chenjiang You. Structural and functional characteristics of plant PHD domain-containing proteins [J]. Hereditas(Beijing), 2021, 43(4): 323-339.
[2]	Wenjing Zhu, Zhiwei Liu. MDMPR: Mouse Developmental and Metabolic Phenotype Repository [J]. Hereditas(Beijing), 2021, 43(4): 375-384.
[3]	Xiangqian Zhang, Nan Li, Xinming Xie. Design and exploration of epigenetic comprehensive experiments [J]. Hereditas(Beijing), 2021, 43(12): 1179-1187.
[4]	Yingchu Hu, Haochang Hu, Shaoyi Lin, Xiaomin Chen. The role of DNA hydroxymethylation in the regulation of atherosclerosis [J]. Hereditas(Beijing), 2020, 42(7): 632-640.
[5]	Zhichao Mei, Zhujun Wei, Jiahui Yu, Fengdan Ji, Linan Xie. Multi-omics association analysis revealed the role and mechanism of epialleles in environmental adaptive evolution of Arabidopsis thaliana [J]. Hereditas(Beijing), 2020, 42(3): 321-331.
[6]	Jingwen Zhang,Qian Xu,Guoliang Li. Epigenetics in the genesis and development of cancers [J]. Hereditas(Beijing), 2019, 41(7): 567-581.
[7]	Zhu Ya'nan, Ying Ao, Bin Li, Yang Wan, Hui Wang. Developmental disorder of podocytes and the related renal diseases [J]. Hereditas(Beijing), 2018, 40(2): 116-125.
[8]	Tiangong Wang, Meng Ye. Advances on the roles of m ⁶A in tumorigenesis [J]. Hereditas(Beijing), 2018, 40(12): 1055-1065.
[9]	Qingyun Chen,Youzhi Li,Xianwei Fan. Molecule mechanism for regulating stomatal development in plants [J]. Hereditas(Beijing), 2017, 39(4): 302-312.
[10]	Min Yue, Yu Yang, Gaili Guo, Ximing Qin. Genetic and epigeneticregulations of mammalian circadian rhythms [J]. Hereditas(Beijing), 2017, 39(12): 1122-1137.
[11]	Yuanfeng Li, Yubo Han, Pengbo Cao, Jinfeng Meng, Haibei Li, Geng Qin, Feng Zhang, Guangfu Jin, Yong Yang, Lingqian Wu, Jie Ping, Gangqiao Zhou. Research advances on medical genetics in China in 2015 [J]. HEREDITAS(Beijing), 2016, 38(5): 363-390.
[12]	Lingyun Sun, Xingyu Li, Zhiwei Sun. Progress of epigenetics and its therapeutic application in hepatocellular carcinoma [J]. HEREDITAS(Beijing), 2015, 37(6): 517-527.
[13]	Caifang Ren, Hongyan Sun, Lizhong Wang, Guomin Zhang, Yixuan Fan, Guangyao Yan, Dan Wang, Feng Wang. Reprogramming mechanism and genetic stability of induced pluripotent stem cells (iPSCs) [J]. HEREDITAS(Beijing), 2014, 36(9): 879-887.
[14]	Dajun Deng. DNA methylation and demethylation: current status and future per-spective [J]. HEREDITAS(Beijing), 2014, 36(5): 403-410.
[15]	Kexue Ma, Keshi Ma, Xingzi Xi. Research progress of epigenetic transgenerational phenotype [J]. HEREDITAS(Beijing), 2014, 36(5): 476-484.