癌症发生发展中的表观遗传学研究

doi:10.16288/j.yczz.19-077

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (7): 567-581.doi: 10.16288/j.yczz.19-077

• Review • Next Articles

Epigenetics in the genesis and development of cancers

Jingwen Zhang,Qian Xu,Guoliang Li()

College of Informatics, National Key Laboratory of Crop Genetic Improvement, Agricultural Bioinformatics Key Laboratory of Hubei Province, Hubei Engineering Technology Research Center of Agricultural Big Data, Huazhong Agricultural University, Wuhan 430070, China

Received:2019-05-03 Revised:2019-06-08 Online:2019-07-20 Published:2019-06-11
Contact: Li Guoliang E-mail:guoliang.li@mail.hzau.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(31771402);Fundamental Research Funds for the Central Universities(2662017PY116)

Abstract

Abstract:

Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA methylation, and changes in the three-dimensional conformation of chromatin, can interfere with gene expression to some extent, and result in cancers. This review provides a brief overview of epigenetics, focusing on their association with the genesis of cancers, and we look forward to the application of epigenetics in cancer clinical diagnosis and treatment.

Key words: cancers, epigenetics, DNA/RNA methylation, histone modification, nucleosome positioning, non-coding RNA, chromatin three-dimensional structure

Jingwen Zhang,Qian Xu,Guoliang Li. Epigenetics in the genesis and development of cancers[J]. Hereditas(Beijing), 2019, 41(7): 567-581.

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