STIM1在肿瘤发生及转移中的研究进展

doi:10.16288/j.yczz.23-035

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Hereditas(Beijing) ›› 2023, Vol. 45 ›› Issue (5): 395-408.doi: 10.16288/j.yczz.23-035

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The roles and mechanism of STIM1 in tumorigenesis and metastasis

Chenghao Yan¹(), Weiyu Bai¹(), Zhimeng Zhang¹, Junling Shen¹, Youjun Wang²(), Jianwei Sun¹()

1. Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650504, China
2. Beijing Key Laboratory of Gene Resources and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China

Received:2023-02-18 Revised:2023-04-03 Online:2023-05-20 Published:2023-04-17
Contact: Wang Youjun,Sun Jianwei E-mail:ych9702@126.com;weiyubai@mail.ynu.edu.cn;jwsun@ynu.edu.cn;wyoujun@bnu.edu.cn
Supported by:
National Natural Science Foundation of China Nos(82273460);National Natural Science Foundation of China Nos(32260167);Yunnan University Graduate Research Innovation Project(2021Z088);Yunnan University Graduate Research Innovation Project(2023Y0222)

Abstract

Abstract:

STIM1 (stromal interaction molecule 1) is one of the key components of the store operated Ca²⁺ entry channel (SOCE), which is located on the endoplasmic reticulum membrane and highly expressed in most kinds of tumors. STIM1 promotes tumorigenesis and metastasis by modulating the formation of invadopodia, promoting angiogenesis, mediating inflammatory response, altering the cytoskeleton and cell dynamics. However, the roles and mechanism of STIM1 in different tumors have not been fully elucidated. In this review, we summarize the latest progress and mechanisms of STIM1 in tumorigenesis and metastasis, thereby providing insights and references for the study on STIM1 in the field of cancer biology in the future.

Key words: STIM1, SOCE, tumorigenesis, metastasis

Chenghao Yan, Weiyu Bai, Zhimeng Zhang, Junling Shen, Youjun Wang, Jianwei Sun. The roles and mechanism of STIM1 in tumorigenesis and metastasis[J]. Hereditas(Beijing), 2023, 45(5): 395-408.

Figures/Tables 2

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The roles and mechanism of STIM1 in tumorigenesis and metastasis

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