核糖体DNA转录的表观调控与肿瘤发生

doi:10.16288/j.yczz.18-244

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Hereditas(Beijing) ›› 2019, Vol. 41 ›› Issue (3): 185-192.doi: 10.16288/j.yczz.18-244

• Review • Next Articles

The epigenetic regulation of ribosomal DNA and tumorigenesis

Xiangrong Cheng,Xinglin Hu,Qi Jiang,Xingwei Huang,Nan Wang,Lei Lei()

Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China

Received:2018-10-15 Revised:2019-01-15 Online:2019-02-25 Published:2019-02-18
Contact: Lei Lei E-mail:leiys2002@yahoo.com
Supported by:
Supported by the National Natural Science Foundation of China(No. 31671545)

Abstract

Abstract:

Recent research in epigenetics suggests that defects in epigenetic regulation of ribosomal DNA (rDNA) transcription may contribute to tumorigenesis. ATRX/DAXX complex is involved in the establishment and maintenance of the silence of the rDNA gene through H3K9me3 modification at histone variant H3.3. The ATRX/DAXX-related genes are frequently mutated in some types of tumors, which may increase rDNA transcription and promote cancer development and progression. In this review, we focus on the mechanism that abnormal transcription of rDNA potentially influences tumorigenesis. We also summarize the epigenetic regulatory mechanism of rDNA transcription, which may provide new theoretical support for drug development based on rDNA transcriptional regulation.

Key words: rDNA, epigenetic regulation, H3.3, ATRX/DAXX, tumorigenesis

Xiangrong Cheng,Xinglin Hu,Qi Jiang,Xingwei Huang,Nan Wang,Lei Lei. The epigenetic regulation of ribosomal DNA and tumorigenesis[J]. Hereditas(Beijing), 2019, 41(3): 185-192.

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