真核生物mRNA 3′非翻译区最新研究进展

doi:10.16288/j.yczz.24-283

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Hereditas(Beijing) ›› 2025, Vol. 47 ›› Issue (6): 616-624.doi: 10.16288/j.yczz.24-283

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Recent advances in the study of 3′ untranslated regions of eukaryotic mRNAs

Haoyu Luo¹^,²^,³(), Xiaohong Yan¹^,²^,³, Fang Mu¹^,²^,³, Ning Wang¹^,²^,³()

1. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs, Harbin 150030, China
2. Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China
3. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China

Received:2024-09-27 Revised:2025-02-20 Online:2025-06-20 Published:2025-02-25
Contact: Ning Wang E-mail:luohaoyu@neau.edu.cn;wangning@neau.edu.cn
Supported by:
National Natural Science Foundation of China(U23A20230);Natural Science Fund for Outstanding Youth of Heilongjiang Province(YQ2023C008);China Agriculture Research System of MOF and MARA(CARS-41)

Abstract

Abstract:

The 3′ untranslated regions (3′UTRs) are a component of eukaryotic messenger RNAs (mRNAs) and located at their 3′-most ends. 3′UTRs play crucial roles in post-transcriptional regulation of gene expression, regulating cleavage and polyadenylation, mRNA stability, mRNA translation and localization. With deepening research of the 3′UTRs, and with advent of various omics methods, a few unexpected functions of the eukaryotic 3′UTRs have been uncovered. In this review, we summarize recent advances in the study of 3′UTRs and propose the future research directions for studying the roles and mechanisms of the 3′UTRs, with the aim to provide a better reference for comprehensively investigating gene function and regulation.

Key words: gene, 3′ untranslated region (3′UTR), post-transcritional regulation, isolated 3′UTR (i3′UTR), protein multifunctionality

Haoyu Luo, Xiaohong Yan, Fang Mu, Ning Wang. Recent advances in the study of 3′ untranslated regions of eukaryotic mRNAs[J]. Hereditas(Beijing), 2025, 47(6): 616-624.

Figures/Tables 2

References 40

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Recent advances in the study of 3′ untranslated regions of eukaryotic mRNAs

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