人染色体8p11(CHRNB3-CHRNA6)区域基因多态性与中国汉族人群肺癌易感性的相关性

doi:10.3724/SP.J.1005.2011.00886

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (8): 886-894.doi: 10.3724/SP.J.1005.2011.00886

Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population

ZHANG Xiao-Bo¹, ZHAO Zhen-Hong¹, CHEN Hong-Yan¹, WANG Jiu-Cun¹, QIAN Ji¹, YANG Ya-Jun¹, WEI Qing-Yi², HUANG Jian³, LU Da-Ru¹

1. State key laboratory of Genetic Engineering, The Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China 2. Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, TX 77030-3721, USA 3. Department of Biochemistry and Molecular Cell Biology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China

Received:2011-04-14 Revised:2011-05-11 Online:2011-08-20 Published:2011-08-25
Contact: Lu Daru E-mail:drlu@fudan.edu.cn

Abstract

Abstract: To investigate the association between chromosome 8p11 (CHRNB3-CHRNA6) polymorphisms and lung cancer susceptibility in Chinese Han population, we genotyped 6 tag SNPs variants of this region among 784 patients with lung cancer and 782 age- and sex-matched cancer-free control participants to screen for any risk-associated SNPs. The results revealed that rs16891561 TT genotype had a protective effect against lung cancer in people over 60 years old (ad-justed OR=0.42, 95% CI=0.20-0.88; P=0.022), female groups (adjusted OR=0.34, 95% CI=0.13-0.87; P=0.025), and non-smoking people (adjusted OR=0.32, 95% CI=0.13-079; P=0.013). Additionally, rs4236926 TT genotype had a protective effect against lung cancer in people over 60 years old (adjusted OR=0.48, 95% CI=0.23-0.99; P=0.048) and non-smoking people (adjusted OR=0.32, 95% CI=0.13-0.80; P=0.014). According to pathological type of lung cancer, these two SNPs were associated with adenocarcinomas susceptibility. As to cumulative effect of rs4236926 and rs16891561, in non-smokers strata, lung cancer risk was significantly reduced in those who had 3-4 mutant alleles (adjusted OR=0.29, 95% CI=0.11-0.71; P=0.007). Furthermore, people containing 3-4 mutant alleles had lower level of smoking doses (mean pack-year=13.2) compared with others. In conclusion, 8p11 (CHRNB3-CHRNA6) polymorphisms are related to smoking behavior and lung cancer susceptibility in Chinese Han population.

Key words: 8p11, CHRNB3, CHRNA6, single nucleotide polymorphism, lung cancer susceptibility

ZHANG Xiao-Bo, DIAO Zhen-Hong, CHEN Gong-Yan, WANG Jiu-Cun, JIAN Ji, YANG E-Jun, WEI Qiang-Xi, HUANG Jian, LEI Da-Ru. Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population[J]. HEREDITAS, 2011, 33(8): 886-894.

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Human chromosome 8p11 (CHRNB3-CHRNA6) region gene polymorphisms and susceptibility to lung cancer in Chinese Han population

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