中国荷斯坦牛POU1F1基因与PRL基因的多态性及其聚合效应对产奶性状的影响

doi:10.3724/SP.J.1005.2011.01359

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (12): 1359-1365.doi: 10.3724/SP.J.1005.2011.01359

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Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Hol-stein cattle

JIA Xiang-Jie^1,2, WANG Chang-Fa¹, YANG Gui-Wen³, HUANG Jin-Ming¹, LI Qiu-Ling¹, ZHONG Ji-Feng¹

1. Dairy Cattle Research Center, Shandong Academy of Agricultural Science, Jinan 250100, China 2. Zaozhuang Vocational College of Science & Technology, Tengzhou 277500, China 3. College of Life Science, Shandong Normal University, Jinan 250014, China

Received:2011-03-15 Revised:2011-07-20 Online:2011-12-20 Published:2011-12-25

Abstract

Abstract: Three novel SNPs were found by DNA sequencing, PCR-RFLP and CRS-PCR methods were used for genotyping in 979 Chinese Holstein cattle. One SNP, G1178C, was identified in exon 2 of POU1F1 gene. Two novel SNPs, A906G and A1134G, were identified in 5′-flanking regulatory region (5′-UTR) of PRL gene. The association between poly-morphisms of the two genes and milk performance traits were analyzed with PROC GLM of SAS. The results showed that GC genotype at 1178 locus of POU1F1 gene was advantageous for milk yield, milk protein yield, and milk fat yield. AG genotype at 906 locus was advantageous for milk yield. There was no significant difference between 1134 locus and milk performance traits of 5′-UTR of PRL gene. Analysis of genotype combination effect on milk production traits showed that the effect of combined genotype was not simple sum of single genotypes and the effects of gene pyramiding seemed to be more important in molecular breeding.

Key words: Chinese Holstein cattle, POU1F1, PRL, polymorphism, milk performance traits, combined effects

CLC Number:

s813.3

JIA Xiang-Jie, WANG Chang-Fa, YANG Gui-Wen, HUANG Jin-Ming, LI Qiu-Ling, ZHONG Ji-Feng. Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Hol-stein cattle[J]. HEREDITAS, 2011, 33(12): 1359-1365.

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Polymorphism of POU1F1 gene and PRL gene and their combined effects on milk performance traits in Chinese Hol-stein cattle

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