中国湖北地区汉族家系补体第四成本(C4)单倍型的检测

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HEREDITAS ›› 1991, Vol. 18 ›› Issue (3): 193-199.

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Investigation of C4 Haplotypes in Han Nationality of Hubei Province in China

Wang Ce, Yao Zhu, Zhang Wenjie, Nie Xiaobo,Zhao Xiuzhu

Sino-Australia Friendship Laboratory of Complement,Department of Pathophysiology ,Tongji Medical University,Wuhan,China 430030

Received:1900-01-01 Revised:1900-01-01

Abstract

Abstract: C4 baplotypes of 93 unrelated families of Han nationality in Hubei Province were determined by means of a method established in our laboratory based on the tech niques recommended in the 4th International WOrkshop for the Genetics of Complem ent and the method of Carboxype-ptidase B developed by Zhang in Australia.310 C4 haplotypes were analysed.The haplotype frequency of A3B1 (0.4194) was found to be the highest in Han nationality of Hubei in China.The others are as follows:A3 B2:0.1161,A2B1 and A4B2:both 0.0903,AQOB1:0.0645,A3BQO:0.0548,AQOBQO:0.0322,A2B2 :0.0256,A4B1:0.0161,A2B92:0.0129.Some kinds of rare haplotypes were also discove red.Significant positive-linkage disequilibrium parameters (Δ) were found in ha plotypes of A4B2,AQOBQO and A2B92,while the significant negative Δ was observed in that of A4B1 and AQOB2.Our data were compared with those of Japanese,Caucasi an in USA and Germany,Negroids in South Africa.are discussed in the paper The di fferences among them.

Key words: Haplotype, C4, Complement

Wang Ce, Yao Zhu, Zhang Wenjie, Nie Xiaobo, Zhao Xiuzhu. Investigation of C4 Haplotypes in Han Nationality of Hubei Province in China[J]. HEREDITAS, 1991, 18(3): 193-199.

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Investigation of C4 Haplotypes in Han Nationality of Hubei Province in China

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