Lipin家族研究进展

doi:10.3724/SP.J.1005.2010.00981

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (10): 981-993.doi: 10.3724/SP.J.1005.2010.00981

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Research and development of Lipin family

TANG Sheng-Qiu¹, JIANG Qing-Yan², YANG Chu-Fen³, ZOU Xiao-Ting⁴, DONG Xiao-Ying¹

1. College of Yingdong Bioengineering, Shaoguan University, Shaoguan 512005, China;
2. College of Animal Science, South China Agricultural University, Guangzhou 510642, China;
3. Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;
4. Institute of Feed Science, Zhejiang University, Hangzhou 310029, China

Received:2010-01-06 Revised:2010-04-08 Online:2010-10-20 Published:2010-10-20
Contact: DONG Xiao-Ying E-mail:dongcathy@163.com

Abstract

Abstract: Lipin family including at least three members Lipin 1, Lipin 2, and Lipin 3 is a critical regulatory enzyme identified recently, which plays dual roles in lipid metabolisms. Lipin family has physiological effects not only on regulating lipid metabalism, but also on maintaining normal peripheral nervous functions, liver lipoprotein secretion, cell morphous, reproductive functions, and energy homeostasis. Since mutations in Lipin gene express may be associated with AIDS, insulin resistance, obesity, diabetes mellitus, and the other diseases of metabolic syndrome, Lipin may be a new useful target in treatment of above-mentioned clinical-related diseases. In this article, we focused on discovery, construction features, expression, regulatory mechanism, and biological functions of Lipin, as well as its correlation research with clinical-related diseases.

Key words: biological function, clinical-related diseases, lipin, lipid metabolism

TANG Qing-Qiu, JIANG Jing-Yan, YANG Chu-Fen, JU Xiao-Ting, DONG Xiao-Yang. Research and development of Lipin family[J]. HEREDITAS, 2010, 32(10): 981-993.

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