SNCA基因在酒精依赖遗传机制中的研究进展

doi:10.3724/SP.J.1005.2010.01114

[an error occurred while processing this directive]

HEREDITAS ›› 2010, Vol. 32 ›› Issue (11): 1114-1118.doi: 10.3724/SP.J.1005.2010.01114

• en • Previous Articles Next Articles

Inheritance machnisam of gene SNCA for alcohol dependence

YANG Yong-Qiang^{1, 2}, LI Fan¹

1. Department of Forensic Medicine, Henan University of Science＆Technology, Luoyang 471003, China; 2. Hospital Teaching Office, Xuchang Central Hospital, Xuchang 461000, China

Received:2010-01-29 Revised:2010-05-19 Online:2010-11-20 Published:2010-11-25
Contact: LI Fan E-mail:fanlfy@mail.haust.edu.cn

Abstract

Abstract: SNCA gene is located in a quantitative trait locus for alcohol preference. α-synuclein coded by SNCA gene can regulate the function of dopamine in multiple levels, and dopamine is an important neurotransmitter in alcohol preference. Variation has been found in SNCA gene carried by alcohol-dependent patients. Meanwhile, significant increase of SNCA gene expression also occurs in alcohol-dependent patients, which is closely associated with the level of alcohol dependence. Therefore, SNCA gene is believed to contribute to genetic mechanism of alcohol dependence. Here, the relationship between SNCA gene and dopamine, the variation and expression of SNCA gene in alcohol-dependent patients were reviewed.

Key words: SNCA gene, dopamine, alcohol dependence, genetic mechanism

YANG Yong-Jiang, LI Fan. Inheritance machnisam of gene SNCA for alcohol dependence[J]. HEREDITAS, 2010, 32(11): 1114-1118.

References

[1] 贺艮峰, 钟树荣, 景强. 酒精依赖相关基因的遗传多态性. 遗传, 2008, 30(4): 413–418. [2] Liang TB, Spence J, Liu LX, Strother WN, Chang HW, Ellison JA, Lumeng L, Li TK, Foroud T, Carr LG. α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alco-hol-preferring and -nonpreferring rats. Proc Natl Acad Sci USA, 2003, 100(8): 4690–4695. [3] Farrer M. The Genetics and molecular biology of al-pha-synuclein. Handb Clin Neurol, 2008, 89: 313–319. [4] Spence JP, Liang TB, Liu LX, Johnson PL, Foroud T, Carr LG, Shekhar A. From QTL to candidate gene: a genetic approach to alcoholism research. Curr Drug Abuse Rev, 2009, 2(2): 127–134. [5] Pankratz N, Nichols WC, Elsaesser VE, Pauciulo MW, Marek DK, Halter CA, Wojcieszek J, Rudolph A, Pfeiffer RF, Foroud T, Parkinson Study Group-PROGENI Investi-gators. Alpha-synuclein and familial Parkinson's disease. Mov Disord, 2009, 24(8): 1125–1131. [6] Perez RG, Waymire JC, Lin E, Liu JJ, Guo FL, Zigmond MJ. A role for α-synuclein in the regulation of dopamine biosynthesis. J Neurosci, 2002, 22(8): 3090–3099. [7] Tehranian R, Montoya SE, van Laar AD, Hastings TG, Perez RG. Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J Neurochem, 2006, 99(4): 1188–1196. [8] Liu DM, Jin L, Wang H, Zhao HY, Zhao CL, Duan CL, Lu LL, Wu B, Yu S, Chan P, Li YH, Yang H. Silencing α-synuclein gene expression enhances tyrosine hydroxy-lase activity in MN9D cells. Neurochem Res, 2008, 33(7): 1401–1409. [9] Peng XM, Tehranian R, Dietrich P, Stefanis L, Perez RG. α-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. J Cell Sci, 2005, 118(15): 3523–3530. [10] Baptista MJ, O'Farrell C, Daya S, Ahmad R, Miller DW, Hardy J, Farrer MJ, Cookson MR. Co-ordinate transcrip-tional regulation of dopamine synthesis genes by al-pha-synuclein in human neuroblastoma cell lines. J Neu-rochem, 2003, 85(4): 957–968. [11] Yu S, Zuo XH, Li YH, Zhang C, Zhou M, Zhang YA, Uéda K, Chan P. Inhibition of tyrosine hydroxylase ex-pression in alpha-synuclein-transfected dopaminergic neu-ronal cells. Neurosci Lett, 2004, 367(1): 34–39. [12] Gao N, Li YH, Li X, Yu S, Fu GL, Chen B. Effect of α-synuclein on the promoter activity of tyrosine hydroxy-lase gene. Neurosci Bull, 2007, 23(1): 53–57. [13] Jenco JM, Rawlingson A, Daniels B, Morris AJ. Regula-tion of phospholipase D2: selective inhibition of mam-malian phospholipase D isoenzymes by α- and β-synucleins. Biochemistry, 1998, 37(14): 4901-4909. [14] Murphy DD, Rueter SM, Trojanowski JQ, Lee VM. Synu-cleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in pri-mary hippocampal neurons. J Neurosci, 2000, 20(9): 3214–3220. [15] Lotharius J, Barg S, Wiekop P, Lundberg C, Raymon HK, Brundin P. Effect of mutant α-synuclein on dopamine homeostasis in a new human mesencephalic cell line. J Biol Chem, 2002, 277(41): 38884–38894. [16] Larsen KE, Schmitz Y, Troyer MD, Mosharov E, Dietrich P, Quazi AZ, Savalle M, Nemani V, Chaudhry FA, Ed-wards RH, Stefanis L, Sulzer D. α-synuclein overexpres-sion in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci, 2006, 26(46): 11915–11922. [17] Abeliovich A, Schmitz Y, Fariñas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JMG, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A. Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron, 2000, 25(1): 239–252. [18] Adamczyk A, Ka?mierczak A, Strosznajder JB. Al-pha-synuclein and its neurotoxic

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Inheritance machnisam of gene SNCA for alcohol dependence

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	Xinyuan Wang, Rui Sun, Yuanqing Gao. Advances in genetic mechanisms of hypothalamic dysfunction in Prader-Willi syndrome [J]. Hereditas(Beijing), 2022, 44(10): 899-912.
[2]	Xiaohong He, Lin Jiang, Yabin Pu, Qianjun Zhao, Yuehui Ma. Progress on genetic mapping and genetic mechanism of cattle and sheep horns [J]. Hereditas(Beijing), 2021, 43(1): 40-51.
[3]	Ruoyang Zhao, Yiping Zhao, Bei Li, Gerelchimeg Bou, Xinzhuang Zhang, Togtokh Mongke, Tugeqin Bao, Shurenchimeg Gereliin, Tsimbai Gereltuuin, Chao Li, Dongyi Bai, Manglai Dugarjaviin. Overview of the genetic control of horse coat color patterns [J]. Hereditas(Beijing), 2018, 40(5): 357-368.
[4]	Chao Yang, Ruifu Yang, Yujun Cui. Bacterial genome-wide association study: methodologies and applications [J]. Hereditas(Beijing), 2018, 40(1): 57-65.
[5]	Pinghua Li, Xiang Ma, Yeqiu Zhang, Qian Zhang, Ruihua Huang. Progress in the physiological and genetic mechanisms underlying the high prolificacy of the Erhualian pig [J]. Hereditas(Beijing), 2017, 39(11): 1016-1024.
[6]	Liqin Yin, Shaohong Fu, Jin Yang, Yun Li, Jisheng Wang, Maolin Wang. Generation, identification, formation mechanism and application of plant haploids [J]. Hereditas(Beijing), 2016, 38(11): 979-991.
[7]	Xiaohua Yang, Huafeng Zhang, Jianghua Lai. Alcohol dependence mediated by monoamine neurotransmitters in the central nervous system [J]. HEREDITAS, 2014, 36(1): 11-20.
[8]	LAI Ping, WANG Ping-Qing, ZHANG Bao-Yun, CHU Ming-Xing, LIU Chong-Xu, TAN Ying, FAN Qi. The neuroendocrine regulatory mechanisms of mammalian seasonal reproduction [J]. HEREDITAS, 2012, 34(3): 281-288.
[9]	WANG Hua-Jing, ZHONG Shu-Rong, BAO Jian-Jun, DOU Shao-Jing, WU Wen-Yu, JING Jiang. Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population [J]. HEREDITAS, 2011, 33(1): 48-53.
[10]	HE Gen-Feng, ZHONG Shu-Rong, JING Qiang. Genetic polymorphism for genes of alcohol dependence [J]. HEREDITAS, 2008, 30(4): 413-418.