G蛋白偶联受体3：调控神经系统和卵泡发育的关键因子

doi:10.3724/SP.J.1005.2013.00578

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HEREDITAS ›› 2013, Vol. 35 ›› Issue (5): 578-586.doi: 10.3724/SP.J.1005.2013.00578

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G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development

ZHANG Bao-Le^1,2, GAO Dian-Shuai¹, XU Yin-Xue²

1. Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, China 2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

Received:2012-08-27 Revised:2012-09-26 Online:2013-05-20 Published:2013-05-25

Abstract

Abstract: G protein-coupled receptors (GPCRs), the largest cell surface receptor superfamily, are involved in many physiological and pathological processes. G protein-coupled receptor 3 (Gpr3) is a newly discovered sphingosine 1-phosphate receptor, which directly or indirectly takes part in regulating the processes of nervous system and follicle development in the vertebrates. As a potential therapeutic drug target for a variety of neurological diseases and premature ovarian failure, its physiological function and biological mechanisms deserve further studies. In this paper, we reviewed the functions of Gpr3 in the processes of nervous system development and ovarian follicular development in the vertebrates.

Key words: G protein-coupled receptors, Gpr3, nervous system, follicular development, meiosis

ZHANG Bao-Le GAO Dian-Shuai XU Yin-Xue. G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development[J]. HEREDITAS, 2013, 35(5): 578-586.

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G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development

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