基因转录后调控在DNA损伤反应中的重要功能

doi:10.3724/SP.J.1005.2014.0309

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HEREDITAS ›› 2014, Vol. 36 ›› Issue (4): 309-318.doi: 10.3724/SP.J.1005.2014.0309

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The post-transcriptional regulation of the DNA damage response

Deling Lin^1,2, Ying Luo¹, Yi Song²

1. Medical Faculty of Kunming University of Science and Technology, Kunming 650500, China;
2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China

Received:2013-10-10 Revised:2014-01-08 Online:2014-04-20 Published:2014-03-20

Abstract

Abstract:

In response to DNA damage, a complex signaling network called DNA damage response (DDR) would be activated in cells, to arrest the cell cycle and initiate DNA repair. Previous studies were mainly focused on the transcriptional regulation of gene and covalent modification of protein . In recent years, mRNA stability and translation in DDR attracted more and more attention. Emerging evidence suggests that microRNAs and RNA-binding proteins (RBPs) play critical roles in protecting the heritable genome through participating in the regulation of the DNA damage response. In this review, we discuss the most recent findings regarding the post-transcriptional regulation of the DDR by microRNAs and RBPs.

Key words: DNA damage response, microRNAs, RNA-binding protein, post-transcriptional regulation

Deling Lin, Ying Luo, Yi Song. The post-transcriptional regulation of the DNA damage response[J]. HEREDITAS, 2014, 36(4): 309-318.

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