甲状旁腺激素样激素在胚胎发育中的作用

doi:10.3724/SP.J.1005.2014.0871

[an error occurred while processing this directive]

HEREDITAS(Beijing) ›› 2014, Vol. 36 ›› Issue (9): 871-878.doi: 10.3724/SP.J.1005.2014.0871

• Reviews • Previous Articles Next Articles

Role of parathyroid hormone-like hormone during embryonic development

Yuanyuan Li^{1, 2}, Lei Guo², Shengsheng Lu¹, Zhiming Han²

1. College of Animal Science and Technology, Guangxi University, Nanning 530004, China; 2. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

Received:2014-04-29 Online:2014-09-20 Published:2014-09-20

Abstract

Abstract: Parathyroid hormone-like hormone (PTHLH), also known as parathyroid hormone-related protein (PTHrP), was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcaemia in malignancies. Subsequent studies demonstrated that PTHLH has multiple physiological functions in many fetal and adult tissues, including the regulation of morphogenesis, cell proliferation and differentiation, and transplacental calcium transport. This review focuses on the biological characteristics of PTHLH and its function during embryonic development. The signaling pathway and potential mechanism involved are further discussed.

Key words: parathyroid hormone-like hormone, embryonic development, signaling pathway

Yuanyuan Li, Lei Guo, Shengsheng Lu, Zhiming Han. Role of parathyroid hormone-like hormone during embryonic development[J]. HEREDITAS(Beijing), 2014, 36(9): 871-878.

References

[1] JM, Kubota M, Diefenbach-Jagger H, Wettenhall RE, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA , 1987, 84(14): 5048-5052.
[2] LJ, Winslow GA, Wettenhall RE, Hammonds RG, Moseley JM, Diefenbach-Jagger H, Rodda CP, Kemp BE, Rodrigue H, Chen EY. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science , 1987, 237(4817): 893-896.
[3] C, Burton PBJ, Malik AN, Dixit M, Banga JP, Nicolaides K, Quirke P, Knight DE, McGregor AM. Parathyroid hormone-related peptide in normal human fetal development . J Mol Endocrinol , 1990, 5(3): 259-266.
[4] B, Lindner V, Massfelder T, Helwig JJ, Simeoni U. Developmental aspects of parathyroid hormone-related protein biology. Semin Perinatol , 2001, 25(2): 76-84.
[5] WM, Wysolmerski JJ, Galbraith S, Holt E, Orloff JJ, Yang KH, Vasavada RC, Weir EC, Broadus AE, Stewart AF. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev , 1996, 76(1): 127-173.
[6] PL, Cardoso JC, Gomes AS, Fuentes J, Power DM, Canário AV. Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken. BMC Evol Biol , 2010, 10: 373.
[7] C, Burtis WJ, Raue F, Birch MA, Gallagher JA. Parathyroid hormone-related peptide and 8701-BC bre-ast cancer cell growth and invasion in vitro : evidence for growth-inhibiting and invasion-promoting effects. Mol Cell Endocrinol , 1995, 111(2): 225-232.
[8] Sirchia R, Pupello D. PTHrP(67-86) regulates the expression of stress proteins in breast cancer cells inducing modiﬁcations in urokinase-plasminogen activator and MMP-1 expression. J Cell Sci , 2003, 116(12): 2421- 2430.
[9] MHC, Briggs LJ, Hu W, Martin TJ, Gillespie MT, Jans DA. Importinβrecognizes parathyroid hormone-rel-ated protein with high affinity and mediates its nuclear import in the absence of importin α. J Biol Chem , 1999, 274(11): 7391-7398.
[10] MH, Hu W, Xiao CY, Gillespie MT, Jans DA. Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related protein. Biochem Biophys Res Commun , 2001, 282(2): 629-634.
[11] JE, Amizuka N, Warshawsky H, Biasotto D, Lanske BM, Goltzman D, Karaplis AC. Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death. Mol Cell Biol , 1995, 15(8): 4064- 4075.
[12] Miguel F, Fiaschi-Taesch N, Lopez-Talavera JC, Takane KK, Massfelder T, Helwig JJ, Stewart AF. The C-terminal region of PTHrP, in addition to the nuclear localization signal, is essential for the intracrine stimulation of proliferation in vascular smooth muscle cells . Endocrinology , 2001, 142(9): 4096-4105.
[13] M, Guo R, Bringhurst R, Henderson JE. The Nucleolar Targeting Signal(NTS) of parathyroid hormone related proteinmediate endocytosis and nucleolar translocation. J Bone Miner Res , 1999, 14(9): 1493-1503.
[14] MM, Levy D, He B, Stregger S, Chen T, Richard S, Henderson JE. Parathyroid hormone related protein interacts with RNA. J Biol Chem , 1999, 274(8): 4832-4838.
[15] JC, Burton DW, Deftos LJ, Hastings RH. A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export. Endocrinology , 2006, 147(2): 990-998.
[16] PV, Heath DA, Beck F. Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol , 1991, 6(3): 281-290.
[17] JM, Hayman JA, Danks JA, Alcorn D, Grill V, Southby J, Horton MA. Immunohistochemical detection of parathyroid hormone-related protein in human fetal epithelia. J Clin Endocrinol Metab , 1991, 73(3): 478-484.
[18] MK, Officer RA, Clement JG, Walker TI, Joss JM, Ingleton PM, Martin TJ, Danks JA. Parathyroid hormone

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Role of parathyroid hormone-like hormone during embryonic development

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Jing’ao Lu, Chunyan Huang, Zhiyin Lin, Zheng Tang, Ning Ma, Zhibin Huang. The role of the cd99l2 gene on leukocyte interstitial migration in zebrafish [J]. Hereditas(Beijing), 2022, 44(9): 798-809.
[2]	Xiangwei Tang, Dan Chu, Saina Yan, Yanfei Yin, Qiao Bian, Bo Weng, Bin Chen, Maoliang Ran. MiR-191 promotes the porcine immature Sertoli cell proliferation by targeting the BDNF gene through activating the PI3K/AKT signaling pathway [J]. Hereditas(Beijing), 2021, 43(7): 680-693.
[3]	Chunxia Zhang, Feng Liu. Regulatory signaling pathways in hematopoietic stem cell development [J]. Hereditas(Beijing), 2021, 43(4): 295-307.
[4]	Guangwei Hu, Zhenzhen Zhang, Huan Gao. Progress on the left-right asymmetry patterning in amphioxus [J]. Hereditas(Beijing), 2021, 43(2): 134-141.
[5]	Beibei Du, Lei Liu, Yangyang Zhu. RNA-binding protein Roquin negatively regulates STING-dependent innate immune response in Drosophila [J]. Hereditas(Beijing), 2020, 42(12): 1201-1210.
[6]	Jingying Zhao, Xiaohua Duan, Qiuting Wang, Ying Huang, Junjing Jia, Tengfei Dou. Progress on signal pathways related to bone metabolism in animals [J]. Hereditas(Beijing), 2020, 42(10): 979-992.
[7]	Lingqian Yin,Jinshan Ran,Jingjing Li,Peng Ren,Xianxian Zhang,Yiping Liu. Genetic regulation of broodiness in poultry [J]. Hereditas(Beijing), 2019, 41(5): 391-403.
[8]	Zhaojie Lyu, Zhihao Wang, Shuxian Lu, Peirong Liu, Jing Tian. Brachydactyly and the molecular mechanisms of digit formation [J]. Hereditas(Beijing), 2019, 41(12): 1073-1083.
[9]	Zhi Yang, Jun Yao, Xin Cao. Roles of the FGF signaling pathway in regulating inner ear development and hair cell regeneration [J]. Hereditas(Beijing), 2018, 40(7): 515-524.
[10]	Shuguo Sun, Shian Wu, Lei Zhang, . The discovery and expansion of Hippo signaling pathway in Drosophila model [J]. Hereditas(Beijing), 2017, 39(7): 537-545.
[11]	Xinyan Ji, Guoxuan Zhong, Bin Zhao. Molecular mechanisms of the mammalian Hippo signaling pathway [J]. Hereditas(Beijing), 2017, 39(7): 546-567.
[12]	Pingping Zhang,Xin Tong,Tianle Zhang,Zichen Li,Qingqiu Gong. The emerging Hippo signaling pathway in plants [J]. Hereditas(Beijing), 2017, 39(7): 568-575.
[13]	Yuan Gu, Lei Zhang, Faxing Yu. Functions and regulations of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis [J]. Hereditas(Beijing), 2017, 39(7): 588-596.
[14]	Siling Fu,Wanying Zhao,Wenjing Zhang,Hai Song,Hongbin Ji,Nan Tang. Hippo signaling pathway in lung development, regeneration, and diseases [J]. Hereditas(Beijing), 2017, 39(7): 597-606.
[15]	Chuanbo Yao, Xin Zhou, Ceshi Chen, Qunying Lei, . The regulatory mechanisms and functional roles of the Hippo signaling pathway in breast cancer [J]. Hereditas(Beijing), 2017, 39(7): 617-629.