北京汉族群体39个短串联重复序列基因座多态性及其遗传关系

doi:10.16288/j.yczz.15-025

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HEREDITAS(Beijing) ›› 2015, Vol. 37 ›› Issue (7): 683-691.doi: 10.16288/j.yczz.15-025

• Research Articles • Previous Articles Next Articles

Genetic variability and phylogenetic analysis of 39 short tandem repeat loci in Beijing Han population

Xiuyan Ruan¹, Weini Wang², Yaran Yang¹, Bingbing Xie^{1, 3}, Jing Chen¹, Yacheng Liu⁴, Jiangwei Yan¹

1. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China;
2. Shenzhen Criminal Science and Technology Institute, Shenzhen 518001, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China;
4. Forensic Science Division, Department of Beijing Public Security, Beijing 100192, China

Received:2015-01-10 Revised:2015-03-17 Online:2015-07-20 Published:2015-07-20

Abstract

Abstract: In this study, we studied the genetic polymorphisms of short tandem repeat (STR) loci from 13 CODIS and 26 non-CODIS system in Beijing Han population for the first time, and established a database of 39 STR loci whose forensic parameters were further evaluated. Our results demonstrated no significant deviation from the Hardy-Weinberg equilibrium of 39 STR loci and no pairwise linkage disequilibrium between them. The power of discriminations, expected heterozygosity, polymorphic information content, and power of exclusion of 39 STR loci ranged from 0.7740-0.9818, 0.6000-0.9350, 0.5317-0.9047 and 0.2909-0.8673. The cumulated discrimination power and cumulative probability of exclusion were 0.999999999999999999999999999999999999999964971 and 0.999999999973878, respectively. Moreover, the genetic distance was calculated based on allele frequency and phylogenetic tree was built using STR loci data from Beijing Han and other 11 Chinese ethnic groups.This study provides important basic data for Chinese forensic DNA database and population genetics database, and has important significance in carrying out forensic individual identification, paternity testing, and population genetic study.

Key words: STRs, genetic variability, Beijing Han population, forensic genetics

Xiuyan Ruan, Weini Wang, Yaran Yang, Bingbing Xie, Jing Chen, Yacheng Liu, Jiangwei Yan. Genetic variability and phylogenetic analysis of 39 short tandem repeat loci in Beijing Han population[J]. HEREDITAS(Beijing), 2015, 37(7): 683-691.

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Genetic variability and phylogenetic analysis of 39 short tandem repeat loci in Beijing Han population

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