NEK家族在细胞周期调控中的作用

doi:10.16288/j.yczz.20-421

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Hereditas(Beijing) ›› 2021, Vol. 43 ›› Issue (7): 642-653.doi: 10.16288/j.yczz.20-421

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Roles of NEK family in cell cycle regulation

Yuanyuan Li¹(), Lei Guo², Zhiming Han^1,³()

1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2. Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
3. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

Received:2021-03-27 Revised:2021-05-12 Online:2021-07-20 Published:2021-06-25
Contact: Han Zhiming E-mail:liyuanyuan891116@163.com;hanzm@ioz.ac.cn
Supported by:
Supported by the National Key R&D Program of China Nos(2018YFC1004000);Supported by the National Key R&D Program of China Nos(2019YFA0109900);the National Natural Science Foundation of China No(31970509)

Abstract

Abstract:

As a serine/threonine kinase, NIMA-related kinases (NEKs) play important roles in the regulation of cell cycle, and involve in several cellular activities such as centrosome separation, spindle assembly, chromatin condensation, nuclear envelope breakdown, spindle assembly checkpoint signaling, cytokinesis, cilia formation and DNA damage response. In this review, we summarize the component, structural characteristics and functions of NEK family in mitosis and meiosis based on the relevant researches in recent years, providing a reference for the further study on the roles of NEKs in the regulation of cell cycle and a theoretical basis for the clinical diagnosis and treatment of tumors.

Key words: NIMA-related kinases, mitosis, meiosis

Yuanyuan Li, Lei Guo, Zhiming Han. Roles of NEK family in cell cycle regulation[J]. Hereditas(Beijing), 2021, 43(7): 642-653.

Figures/Tables 2

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NEK	亚细胞定位	功能
1	细胞质、中心体、纤毛、DNA损伤部位	纤毛发生^[36,37]、DNA损伤反应^[38,39]、线粒体^[39]、纺锤体组装^[40]
2	中心体	有丝分裂^[41]、减数分裂^[42]、纤毛发生^[43,44]
3	细胞质	催乳素依赖性信号传导^[45]
4	纤毛基体、纤毛小根	DNA损伤反应^[46]、微管^[47]、RNA剪接^[48]、纤毛稳定^[49]
5	细胞质、中心体、纺锤体、线粒体	中心体分离^[50]、减数分裂恢复^[51]、DNA损伤反应^[52]、成肌分化^[53]、线粒体^[54,55]
6	细胞质、纺锤体、中心体	有丝分裂^[24,56,57]、DNA损伤反应^[58]、炎症反应^[59]、中心体分离^[23,60]
7	纺锤体两极	中心体分离^[23,60]、炎症反应^[61,62,63]、DNA损伤反应^[64,65]、纺锤体组装^[56,66,67]
8	中心体、纤毛	纤毛发生^[68,69]、DNA损伤反应^[70,71]
9	中心体, 纺锤体两极	纺锤体形成^[72]、中心体成熟和分离^[73]、DNA损伤反应^[74]
10	线粒体	细胞周期^[75]、DNA损伤反应^[75]、线粒体^[76]、纤毛发生^[77]
11	细胞核、核仁、纺锤体	细胞周期^[78,79]、DNA损伤反应^[80]、细胞不对称分裂^[81]

Roles of NEK family in cell cycle regulation

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