N6-腺苷甲基化修饰及其对LINE-1的调控机制

doi:10.16288/j.yczz.23-248

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Hereditas(Beijing) ›› 2024, Vol. 46 ›› Issue (3): 209-218.doi: 10.16288/j.yczz.23-248

• Review • Previous Articles Next Articles

N⁶-adenosine methylation and the regulatory mechanism on LINE-1

Ao Zhang(), Shan Cen(), Xiaoyu Li()

Department of Immunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China

Received:2023-11-10 Revised:2023-12-28 Online:2024-03-20 Published:2024-01-19
Contact: Shan Cen, Xiaoyu Li E-mail:za1632649341@163.com;shancen@hotmail.com;xiaoyulik@hotmail.com
Supported by:
National Natural Science Foundation of China(31870164)

Abstract

Abstract:

Long interspersed elements-1(LINE-1) is the only autonomous transposon in human genome，and its retrotransposition results in change of cellular genome structure and function, leading occurrence of various severe diseases. As a central key intermediated component during life cycle of LINE-1 retrotransposition, the host modification of LINE-1 mRNA affects the LINE-1 transposition directly. N⁶-adenosine methylation(m⁶A), the most abundant epigenetic modification on eukaryotic RNA, is dynamically reversible. m⁶A modification is also found on LINE-1 mRNA, and it participants regulation of the whole LINE-1 replication cycle, with affecting LINE-1 retrotransposition as well as its adjacent genes expression, followed by influencing genomic stability, cellular self-renewal, and differentiation potential, which plays important roles in human development and diseases. In this review, we summarize the research progress in LINE-1 m⁶A modification, including its modification positions, patterns and related mechanisms, hoping to provide a new sight on the mechanism research and treatment of related diseases.

Key words: m⁶A modification, retrotransposon, LINE-1, genome, genome stability

Ao Zhang, Shan Cen, Xiaoyu Li. N⁶-adenosine methylation and the regulatory mechanism on LINE-1[J]. Hereditas(Beijing), 2024, 46(3): 209-218.

Figures/Tables 2

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N⁶-adenosine methylation and the regulatory mechanism on LINE-1

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