冠心病全基因组关联研究进展

doi:10.3724/SP.J.1005.2010.00

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (2): 97-104.doi: 10.3724/SP.J.1005.2010.00

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Advances in genome-wide association study of coronary heart disease

YANG Ying, LU Xiang-Feng

Department of Population Genetics and Prevention, Fu Wai Hospital & Cardiovascular Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China

Received:2009-08-09 Revised:2009-11-13 Online:2010-02-20 Published:2010-02-15
Contact: LU Xiang-Feng E-mail:xiangfenglu@sina.com

Abstract

Abstract:

As a new effective strategy for researching complex diseases, genome-wide association study (GWAS) has being developed rapidly in recent years worldwide. The world genomic study has been taken into a new stage, since a series of disease related genes or variants have been identified by GWAS strategy. Coronary heart disease (CHD) is a complex disease that is caused by both environmental and genetic factors, and has become one of the leading causes of death and disability worldwide. With the application of GWAS strategy, researchers from all over the world have identified many susceptibility loci or regions of CHD that were unable to be identified by candidate gene case-control study. The present paper reviewed the important progresses worldwide attained in GWAS of CHD in recent years. Then it is also expounded the challenges we are facing nowadays in GWAS as well as the future study direction. The information outlined in this paper provides us a valuable guidance upon further exploration into genetic mechanism of CHD.

Key words: genome-wide association study, coronary heart disease, genetic susceptibility loci, replication

YANG Yang, LU Xiang-Feng. Advances in genome-wide association study of coronary heart disease[J]. HEREDITAS, 2010, 32(2): 97-104.

References

[1] Pearson TA, Manolio TA. How to interpret a genome-wide association study. JAMA, 2008, 299(11): 1335–1344.

[2] Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet, 2006, 367(9524): 1747–1757.

[3] Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med, 2006, 3(11): e442.

[4] 卫生部心血管病防治研究中心.《中国心血管病防治报告2007》. 北京: 中国大百科全书出版社, 2009, 55–58.

[5] 卫生部心血管病防治研究中心.《中国心血管病防治报告2005》. 北京: 中国大百科全书出版社, 2006, 45–46.

[6] Ozaki K, Ohnishi Y, Iida A, Sekine A, Yamada R, Tsunoda T, Sato Hir, Sato Hid, Hori M, Nakamura Y, Tanaka T. Functional SNPs in the lymphotoxin-α gene that are asso-ciated with susceptibility to myocardial infarction. Nat Genet, 2002, 32(4): 650–654.

[7] The Wellcome Trust Case Control Consortium. Genome- wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 2007, 447(7145): 661–678.

[8] McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg- Hansen A, Folsom AR, Boerwinkle E, Hobbs HH, Cohen JC. A common allele on chromosome 9 associated with coronary heart disease. Science, 2007, 316(5830): 1488–1491.

[9] Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, Masson G, Gudbjartsson DF, Magnusson KP, Andersen K, Levey AI, Backman VM, Matthiasdottir S, Jonsdottir T, Palsson S, Einarsdottir H, Gunnarsdottir S, Gylfason A, Vaccarino V, Hooper WC, Reilly MP, Granger CB, Austin H, Rader DJ, Shah SH, Quyyumi AA, Gulcher JR, Thorgeirsson G, Thorsteinsdottir U, Kong A, Stefansson K. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science, 2007, 316(5830): 1491–1493.

[10] Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D’Agostino RB Sr, Fox CS, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh C, O'Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham Heart Study 100K project: ge-nome-wide associations for cardiovascular disease out-comes. BMC Med Genet, 2007, 8 (Suppl. 1): S5.

[11] O'Donnell CJ, Cupples LA, D'Agostino RB, Fox CS, Hoffmann U, Hwang SJ, Ingellson E, Liu C, Murabito JM, Polak JF, Wolf PA, Demissie S. Genome-wide association study for subclinical atherosclerosis in major arterial ter-ritories in the NHLBI’s Framingham Hear Study. BMC Med Genet, 2007, 8 (Suppl. 1): S4.

[12] Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, Barrett JH, König IR, Stevens SE, Szymczak S, Tregouet DA, Iles MM, Pahlke F, Pollard H, Lieb W, Cambien F, Fischer M, Ouwehand W, Blankenberg S, Balmforth AJ, Baessler A, Ball SG, Strom TM, Braenne I, Gieger C, Deloukas P, Tobin MD, Ziegler A, Thompson JR, Schunkert H; WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. New Engl J Med, 2007, 357(5): 443–453.

[13] Fischer M, Broeckel U, Holmer S, Baessler A, Hengstenberg C, Mayer B, Erdmann J, Klein G, Riegger G, Jacob HJ, Schunkert H. Distinct heritable patterns of an-giographic coronary artery disease in families with myo-cardial infarction. Circulation, 2005, 111(7): 855–862.

[14] Dorn GW, Sharon Cresci. Genome-wide association stud-ies of coronary artery disease and heart failure: where are we going? Pharmacogenomics, 2009, 10(2): 213–223.

[15] Aulchenko YS, Ripatti S, Lindqvist I, Boomsma D, Heid IM, Pramstaller PP, Penninx BW, Janssens AC, Wilson JF, Spector T, Martin NG, Pedersen NL, Kyvik KO, Kaprio J, Hofman A, Freimer NB,

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