ICSI精子遗传和表观遗传学缺陷

doi:10.3724/SP.J.1005.2010.00289

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (4): 289-294.doi: 10.3724/SP.J.1005.2010.00289

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The genetic and epigenetic defect from the sperm for intracytoplasmic sperm injection (ICSI)

GE Shao-Qin¹, KANG Xian-Jiang², DUAN Fei¹

1. Hebei University Health Science Center, Baoding 071000, China;
2. College of Life Science, Hebei University, Baoding 071000, China

Received:2009-08-16 Revised:2009-10-09 Online:2010-04-20 Published:2010-04-25
Contact: GE Shao-Qin E-mail:gesq67@sina.com; gesq67@163.com

Abstract

Abstract: Intracytoplasmic sperm injection (ICSI) can be applied to treat male infertility patients of oligospermia, asthenospermia, teratospermia, azoospermia and failure of the common in-vitro fertilization (IVF), which may overcome the sperm deficiency and even obtain sperms directly from percutaneous epididymal sperm aspiration (PESA) and testicular sperm extraction (TESE). As for direct injection of a single sperm into an egg, the ICSI disobeys the biological laws of natural insemination, thus leading to high genetic and epigenetic risk for patients owing to genetic and epigenetic defect of sperm. By reviewing the genetic and epigenetic defects of ICSI sperm, as well as related diseases, this article aims at understanding of the risks resulting from the genetic and epigenetic defects of ICSI sperm at a molecular mechanism level. The results show that the quality control of ICSI sperm via detecting its epigenetic factors, such as methylated DNA and acetylated histone, is essential for reducing the genetic and epigenetic risk from ICSI.

Key words: intracytoplasmic sperm injection(ICSI), sperm, genetic, epigenetic, risk

GE Shao-Qin, KANG Xian-Jiang, DUAN Fei. The genetic and epigenetic defect from the sperm for intracytoplasmic sperm injection (ICSI)[J]. HEREDITAS, 2010, 32(4): 289-294.

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