猕猴MHC-DPB1基因外显子2多态性研究

doi:10.3724/SP.J.1005.2010.00588

[an error occurred while processing this directive]

HEREDITAS ›› 2010, Vol. 32 ›› Issue (6): 588-598.doi: 10.3724/SP.J.1005.2010.00588

Polymorphism of MHC-DPB1 gene exon 2 in rhesus macaques (Macaca mulatta)

XU Huai-Liang^{1, 2}, WANG Yan-Ting², CHENG An-Chun^{1, 3}, YAO Yong-Fang², NI Qing-Yong², ZENG Wen³,
BI Feng-Jun³, YANG Ze-Xia³, CHEN Xiao-Yue³

1. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Ya’an 625014, China;
2. College of Animal Science and Technology, Sichuan Agricultural University, Ya’an 625014, China;
3. Engineering and Techonlogy Center for Laboratory Animals of Sichuan Agricultural University, Ya’an 625014, China

Received:2009-11-24 Revised:2010-03-06 Online:2010-06-20 Published:2010-05-24
Contact: CHEN Xiao-Yue3 E-mail:chenganchun@vip.163.com

Abstract

Abstract:

Rhesus macaque (Macaca mulatta) has long been used as an experimental model animal for biomedical research and was under the key state protection (class II) from Chinese government. In order to facilitate the use of Chinese rhesus macaques in biomedical research and their protection based on better understanding of the major mistocompability complex (MHC) genes in these macaques, the exon 2 of Mamu-DPB1 genes were determined in 106 wild rhesus macaques using DGGE, cloning and sequencing. A total of 21 Mamu-DPB1 alleles were obtained, of which 15 alleles were novel sequences that had not been documented previously. Mamu-DPB1*30 was the most frequent allele in the whole large population comprising all 106 rhesus macaque individuals (0.1120) and in Xiaojin population (0.1120), Mamu-DPB1*04 in Heishui (0.1702), -DPB1*32 in Bazhong (0.1613), -DPB1*30 in Hanyuan (0.1120), and -DPB1*04 in Jiulong (0.1139). The alignment of the amino acids sequences showed that 12 variable sites were species-specific, of which 9 sites occurred in the putative amino acids sequences of the 15 novel Mamu-DPB1 alleles. Trans-species polymorphism was observed on the phylogenetic tree based on the DPB1 alleles of rhesus macaques and cynomolgus (Macaca fascicularis). In addition, these results also demonstrated that significant genetic differentiation has occurred between Chinese and Indian rhesus macaque population.

Key words: Macaca mulatta, major histocompatibility complex class II, Mamu-DPB1 gene, polymorphism

XU Fu-Liang, HONG Yan-Ting, CHENG An-Chun, TAO Yong-Fang, NI Qiang-Yong, CENG Wen, BI Feng-Jun, YANG Ze-Xia, CHEN Xiao-Ti. Polymorphism of MHC-DPB1 gene exon 2 in rhesus macaques (Macaca mulatta)[J]. HEREDITAS, 2010, 32(6): 588-598.

References

[1] Lackner AA, Veazey RS. Current concepts in AIDS pathogenesis: insights from the SIV/macaque model. Annu Rev Med, 2007, 58(1): 461–476.

[2] Seggewiss R, Loré K, Guenaga FJ, Pittaluga S, Mattapallil J, Chow CK, Koup RA, Camphausen K, Nason MC, Meier-Schellersheim M, Donahue RE, Blazar BR, Dunbar CE, Douek DC. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood, 2007, 110(1): 441–449.

[3] Vierboom MP, Jonker M, Tak PP, t Hart BA. Preclinical models of arthritic disease in non-human primates. Drug Discov Today, 2007, 12(7–8): 327–335.

[4] Smith DG. Genetic characterization of Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). Comp Med, 2005, 55(3): 227–230.

[5] Boyson JE, Shufflebotham C, Cadavid LF, Urvater JA, Knapp LA, Hughes AL, Watkins DI. The MHC class I genes of the rhesus monkey: Different evolutionary histo-ries of MHC class I and II genes in primates. J Immunol, 1996, 156(12): 4656–4665.

[6] Jones EY, Fugger L, Strominger JL, Siebold C. MHC class II proteins and disease: a structural perspective. Nat Rev Immunol, 2006, 6(4): 271–282.

[7] Rocha N, Neefjes J. MHC class II molecules on the move for successful antigen presentation. EMBO J, 2008, 27(1): 1–5.

[8] 季芳, 饶军华, 刘晓明. 恒河猴主要组织相容性复合体(MHC)的多态性研究概述. 中国比较医学杂志, 2007, 17(7): 420–425.

[9] 陈瑾, 代解杰, 和占龙, 李琦涵, 杨贵波, 孙晓梅. 云南地区恒河猴MHC部分基因频率及多态性的分析. 中国实验动物学报, 2008, 12(6): 410–416.

[10] Doxiadis GG, Otting N, de Groot NG, Bontrop RE. Dif-ferential evolutionary MHC class II strategies in humans and rhesus macaques: relevance for biomedical studies. Immunol Rev, 2001, 183(1): 76–85.

[11] Doxiadis GG, Otting N, de Groot NG, de Groot N, Rou-weler AJ, Noort R, Verschoor EJ, Bontjer I, Bontrop RE. Evolutionary stability of MHC class II haplotypes in di-verse rhesus macaque populations. Immunogenetics, 2003, 55(8): 540–551.

[12] Qiu CL, Yang GB, Yu K, Li Y, Li XL, Liu Q, Zhao H, Xing H, Shao Y. Characterization of the major histocom-patibility complex class II DQB (MhcMamu-DQB1) alleles in a cohort of Chinese rhesus macaques (Macaca mulatta). Hum Immunol, 2008, 69(8): 513–521.

[13] McCanlies EC, Ensey JS, Schuler CR, Kreiss K, Weston A. The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization. Am J Ind Med, 2004, 46(2): 95–103.

[14] Slierendregt BL, Otting N, Kenter M, Bontrop RE. Allelic diversity at the Mhc-DP locus in rhesus macaques (Macaca mulatta). Immunogenetics, 1995, 41(1): 29–37.

[15] Arnold ML, Pei R, Spriewald B, Wassmuth R. Anti-HLA class II antibodies in kidney retransplant patients. Tissue Antigens, 2005, 65(4): 370–378.

[16] Ma X, Tang LH, Qu LB, Ma J, Chen L. Identification of 17 novel major histocompatibility complex-A alleles in a population of Chinese-origin rhesus macaques. Tissue Antigens, 2009, 73(2): 184–187.

[17] Ouyang D, Xu L, Dai Z, Shi H, Zhang G, Zheng Y, He X. Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques. Acta Biochim Bio-phys Sin (Shanghai), 2008, 40(11): 919–927.

[18] Blasky AJ, Karl JA, Wiseman RW, Read DS, O'Connor DH. Rapid high-resolution MHC class I genotyping of Chinese rhesus macaques by capillary reference strand- mediated conformational analysis. Immunogenetics, 2008, 60(10): 575–584.

[19] Otting N, Heijmans CM, van der Wiel M, de Groot NG, Doxiadis GG, Bontrop RE. A snapshot of the Mamu-B genes and their allelic repertoire in rhesus macaques of Chinese origin. Immunogenetics, 2008, 60(9): 507–514

Metrics

Comments

www.chinagene.cn
备案号：京ICP备09063187号

Polymorphism of MHC-DPB1 gene exon 2 in rhesus macaques (Macaca mulatta)

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Xueqian Wang, Qingzhen Zhang, Peng Cheng, Tingting Dong, Weiguo Li, Zhe Zhou, Shengqi Wang. Genetic polymorphisms of 66 InDel loci in the Chinese Han population [J]. Hereditas(Beijing), 2022, 44(4): 335-345.
[2]	Yanyan Cao, Miaomiao Cheng, Fang Song, Yujin Qu, Jinli Bai, Hong Wang. Familial study of spinal muscular atrophy carriers with SMN1 (2+0) genotype [J]. Hereditas(Beijing), 2021, 43(2): 160-168.
[3]	Haoyu Wang, Yuhan Hu, Yueyan Cao, Qiang Zhu, Yuguo Huang, Xi Li, Ji Zhang. AI-SNPs screening based on the whole genome data and research on genetic structure differences of subcontinent populations [J]. Hereditas(Beijing), 2021, 43(10): 938-948.
[4]	Yuzhuo Wang, Yiming Zhang, Xiaolian Dong, Xuecai Wang, Jianfu Zhu, Na Wang, Feng Jiang, Yue Chen, Qingwu Jiang, Chaowei Fu. Modification effects of T2DM-susceptible SNPs on the reduction of blood glucose in response to lifestyle interventions [J]. Hereditas(Beijing), 2020, 42(5): 483-492.
[5]	Qing Zhang,Jie Ping,Haoxiang Zhang,Bo Kang, ,Gangqiao Zhou. Genetic association of MKL1 gene polymorphisms with the high-altitude adaptation [J]. Hereditas(Beijing), 2019, 41(7): 634-643.
[6]	Jieyu Zhang,Yanan Chu,Bingjie Zou,Yanjie Zhang,Liying Feng. Detection of UGT1A16* single nucleotide polymorphism in oral swap samples using the cascade invader assay-based real-time PCR [J]. Hereditas(Beijing), 2018, 40(8): 668-675.
[7]	Zhe-ye Peng,Zi-jun Tang,Min-zhu Xie. Research progress in machine learning methods for gene-gene interaction detection [J]. Hereditas(Beijing), 2018, 40(3): 218-226.
[8]	Lili Liu, Aiwei Guo, Peifu Wu, Fenfen Chen, Yajin Yang, Qin Zhang. Regulation of VPS28 gene knockdown on the milk fat synthesis in Chinese Holstein dairy [J]. Hereditas(Beijing), 2018, 40(12): 1092-1100.
[9]	Wang Shiming, Song Xiao, Zhao Xueying, Chen Hongyan, Wang Jiucun, Wu Junjie, Gao Zhiqiang, Qian Ji, Bai Chunxue, Li Qiang, Han Baohui, Lu Daru. Association between polymorphisms of autophagy pathway and responses in non-small cell lung cancer patients treated with platinum-based chemotherapy [J]. Hereditas(Beijing), 2017, 39(3): 250-262.
[10]	Bengang Wang, Zhi Lv, Qian Xu, Yongfeng Liu. Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection [J]. Hereditas(Beijing), 2017, 39(1): 22-31.
[11]	Mei Fu, Kehui Xu, Wenming Xu. Research advances of Dicer in regulating reproductive function [J]. HEREDITAS(Beijing), 2016, 38(7): 612-622.
[12]	Xian Gong, Chao Zhang, Aisa Yiliyasi, Ying Shi, Xuewei Yang, Aosiman Nuersimanguli, Yaqun Guan, Shuhua Xu. A comparative analysis of genetic diversity of candidate genes associated with type 2 diabetes in worldwide populations [J]. Hereditas(Beijing), 2016, 38(6): 543-559.
[13]	Zhen Liu, Jianhong Xu. The application of the high throughput sequencing technology in the transposable elements [J]. HEREDITAS(Beijing), 2015, 37(9): 885-898.
[14]	Dayan Niu, Weili Yan. The application of genetic risk score in genetic studies of complex human diseases [J]. HEREDITAS(Beijing), 2015, 37(12): 1204-1210.
[15]	Qin Chu, Dong Li, Shiyu Hou, Wanhai Shi, Lin Liu, Yachun Wang. Direct sequencing of DNA pooling for screening highly informative SNPs in dairy cattle [J]. HEREDITAS(Beijing), 2014, 36(7): 691-696.