北极狐GHR基因单核苷酸多态性及其与生长性状的相关性分析

doi:10.3724/SP.J.1005.2010.00599

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (6): 599-605.doi: 10.3724/SP.J.1005.2010.00599

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Association analysis between SNPs of the growth hormone receptor gene and growth traits in arctic fox

DU Zhi-Heng, LIU Zong-Yue, BAI Xiu-Juan

Department of Animal Science, Northeast Agriculture University, Harbin 150030, China

Received:2009-09-15 Revised:2010-02-27 Online:2010-06-20 Published:2010-05-24
Contact: BAI Xiu-Juan E-mail:bxj630306@163.com

Abstract

Abstract:

Using single-strand conformation polymorphism (PCR-SSCP) and DNA sequencing, single nucleotide polymorphisms (SNPs) of growth hormone receptor (GHR) gene were detected in an arctic fox population. Correlation analysis between GHR polymorphisms and growth traits were carried out using the appropriate model. Four SNPs, G3A in the 5′UTR, C99T in the first exon, T59C and G65A in the fifth exon were identified on the arctic fox GHR gene. The G3A and C99T polymorphisms of GHR were associated with female fox body weight (P<0.05) and the T59C and G65A polymorphisms of GHR were associated with male fox body weight (P<0.05) and the skin length of the female fox (P<0.01). Therefore, marker assistant selection on body weight and skin length of arctic foxes using these SNPs can be applied to get big and high quality arctic foxes.

Key words: arctic fox, GHR gene, SNP, growth trait

DU Zhi-Heng, LIU Zong-Yue, BAI Xiu-Juan. Association analysis between SNPs of the growth hormone receptor gene and growth traits in arctic fox[J]. HEREDITAS, 2010, 32(6): 599-605.

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Association analysis between SNPs of the growth hormone receptor gene and growth traits in arctic fox

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