DNA甲基化和组蛋白修饰在克隆动物发育过程中的作用

doi:10.3724/SP.J.1005.2010.00762

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HEREDITAS ›› 2010, Vol. 32 ›› Issue (8): 762-768.doi: 10.3724/SP.J.1005.2010.00762

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Effect of DNA methylation and histone modification during the de-velopment of cloned animals

GUO Lei¹, LI Hui^{1, 2}, HAN Zhi-Ming¹

1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; 2. College of Life Sciences, Beijing Normal University, Beijing 100875, China

Received:2009-11-13 Revised:2010-03-19 Online:2010-08-20 Published:2010-08-23
Contact: HAN Zhi-Ming E-mail:hanzm@ioz.ac.cn

Abstract

Abstract: Somatic cell nuclear transfer (SCNT) has great potential for agricultural applications, generation of medical model animals, transgenic farm animals or generating human embryonic stem cells for treatment of human diseases. Cloned animals derived from somatic cells have been generated in several mammal species, but there are still some unsolved problems with current cloning technology, for example, the low efficiency of animal cloning and the abnormal development of cloned animals. One critical factor of these developmental failures of cloned embryos is the aberrant epigenetic reprogramming. This review focuses on DNA methylation and histone modifications and the relationship between these two epigenetic modifications and the development of cloned embryos. Understanding the mechanisms of epigenetic regulation will be useful to solve the technical problems of SCNT and enable better applications of this technology.

Key words: somatic cell nuclear transfer, epigenetic modification, DNA methylationhistone modifications

GUO Lei, LI Hui, HAN Zhi-Meng. Effect of DNA methylation and histone modification during the de-velopment of cloned animals[J]. HEREDITAS, 2010, 32(8): 762-768.

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Effect of DNA methylation and histone modification during the de-velopment of cloned animals

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