云南汉族人群5-羟色胺转运体基因启动子区多态性与酒精依赖的相关性

doi:10.3724/SP.J.1005.2011.00048

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HEREDITAS ›› 2011, Vol. 33 ›› Issue (1): 48-53.doi: 10.3724/SP.J.1005.2011.00048

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Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population

WANG Xue-Jing¹, ZHONG Shu-Rong¹, BAO Jian-Jun², DOU Shao-Jing¹, WU Wen-Yu², JING Qiang¹

1. Department of Forensic Medicine, Kunming Medical University, Kunming 650500, China;
2. Psychiatric Hospital of Yunnan, Kunming 650224, China

Received:2010-06-03 Revised:2010-08-27 Online:2011-01-20 Published:2010-01-20
Contact: JING Qiang E-mail:zengshi6@public.km.yn.cn

Abstract

Abstract: To explore the association of polymorphism in the serotonin transporter gene and the susceptibility to alcohol dependence in Yunnan Han population, PCR and DNA sequencing techniques were used to detect 5-HTT-linked promoter region (5-HTTLPR). One hundre and eighteen alcohol dependent patients as case group and 214 normal people as control group were employed in this study. Significant differences in genotype frequencies were present between case group and control group of 5-HTTLPR (P<0.05). The proportion of L/L and L/S genotype was significantly smaller in case group than that was in control group (OR=0.581, P=0.026). No significant association was observed in allelic frequencies, which differed in different ethnic groups. In conclusion, 5-HTTLPR polymorphism may be associated with alcohol dependent patients, and the genotype L/L or L/S may be a genetic factor that is responsible for decreasing susceptibility of alcohol dependence in Yunnan Han population.

Key words: alcohol dependence, the serotonin transporter gene, polymorphism, susceptibility

WANG Hua-Jing, ZHONG Shu-Rong, BAO Jian-Jun, DOU Shao-Jing, WU Wen-Yu, JING Jiang. Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population[J]. HEREDITAS, 2011, 33(1): 48-53.

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Association of polymorphism in the serotonin transporter gene promote with the susceptibility to alcohol dependence in Yunnan Han Population

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