Hippo信号通路在果蝇遗传学研究中的发现与扩展

doi:10.16288/j.yczz.17-051

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (7): 537-545.doi: 10.16288/j.yczz.17-051

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The discovery and expansion of Hippo signaling pathway in Drosophila model

Shuguo Sun¹(),Shian Wu²(),Lei Zhang³(),

1. Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. College of Life Science, Nankai University, Tianjin 300071, China
3. Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received:2017-02-18 Revised:2017-04-02 Online:2017-07-20 Published:2017-05-03
Supported by:
the Startup Foundation of Huazhong University of Science and Technology(2016020230)

Abstract

Abstract:

The discovery of Hippo signaling pathway is another breakthrough of fly genetics. Similar to the other signaling pathways, Hippo pathway also functions crucially in tremendous physiological and pathological conditions, like organ size control and cancer. There are three main stages of Hippo pathway study: Firstly, identifications of core components by fly genetic screens; secondly, regulations by versatile upstream cues, like cytoskeleton, mechanical tension, and nutrition; thirdly, functions in different biological processes, like cell proliferation regulation, stem cell biology, and immunology. In this review, we summarize the current understanding of Hippo pathway and highlight its regulations and transcriptional complex assembly. We also discuss the potential future directions in Drosophila model system.

Key words: Hippo signaling pathway, Drosophila, organ size, cell growth

Shuguo Sun, Shian Wu, Lei Zhang, . The discovery and expansion of Hippo signaling pathway in Drosophila model[J]. Hereditas(Beijing), 2017, 39(7): 537-545.

References

[1]	Pan DJ. The Hippo signaling pathway in development and cancer. Dev Cell, 2010, 19(4): 491-505.
[2]	Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev, 1995, 9(5): 534-546.
[3]	Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development, 1995, 121(4): 1053-1063.
[4]	Tapon N, Harvey KF, Bell DW, Wahrer DCR, Schiripo TA, Haber DA, Hariharan IK. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell, 2002, 110(4): 467-478.
[5]	Kango-Singh M, Nolo R, Tao CY, Verstreken P, Hiesinger PR, Bellen HJ, Halder G. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development, 2002, 129(24): 5719-5730.
[6]	Lai ZC, Wei XM, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell, 2005, 120(5): 675-685.
[7]	Wu SA, Huang JB, Dong JX, Pan DJ. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell, 2003, 114(4): 445-456.
[8]	Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol, 2003, 5(10): 914-920.
[9]	Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell, 2003, 114(4): 457-467.
[10]	Jia JH, Zhang WS, Wang B, Trinko R, Jiang J. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. Genes Dev, 2003, 17(20): 2514-2519.
[11]	Pantalacci S, Tapon N, Léopold P. The salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol, 2003, 5(10): 921-927.
[12]	Huang JB, Wu SA, Barrera J, Matthews K, Pan DJ. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP. Cell, 2005, 122(3): 421-434.
[13]	Wu SA, Liu Y, Zheng YG, Dong JX, Pan DJ. The TEAD/TEF family protein scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. Dev Cell, 2008, 14(3): 388-398.
[14]	Zhang L, Ren FF, Zhang Q, Chen YB, Wang B, Jiang J. The TEAD/TEF family of transcription factor scalloped mediates Hippo signaling in organ siz

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