SOX9及其增强子在哺乳动物性别决定中的研究进展

doi:10.16288/j.yczz.24-146

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Hereditas(Beijing) ›› 2024, Vol. 46 ›› Issue (9): 677-689.doi: 10.16288/j.yczz.24-146

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Progress on SOX9 and its enhancers in mammalian sex determination

Min Yang(), Siyuan Lin, Changqi Yang, Yaosheng Chen, Zuyong He()

National Key Laboratory of Aquatic Animal Disease and Healthy Breeding, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China

Received:2024-05-23 Revised:2024-07-04 Online:2024-09-20 Published:2024-08-01
Contact: Zuyong He E-mail:yangmin32@163.com;zuyonghe@foxmail.com
Supported by:
Key R&D Program of Guangdong Province(2018B020203003)

Abstract

Abstract:

The sex determination in mammals refers to the development of an initial bipotential organ, termed the bipotential gonad/genital ridge, into either a testis or an ovary at the early stages of embryonic development, under the precise regulation of transcription factors. SOX9 (SRY-box transcription factor 9) is a multifunctional transcription factor in mammalian development and plays a critical role in sex determination and subsequent male reproductive organs development. Recent studies have shown that several enhancers upstream of SOX9 also play an important role in the process of sex determination. In this review, we summarize the progress on the role of SOX9 and its gonadal enhancers in sex determination. This review will facilitate to understand the regulatory mechanism of sex determination of SOX9 and provides a theoretical basis for the further development of animal sex manipulation technologies.

Key words: mammals, sex determination, SOX9, non-coding region, enhancer

Min Yang, Siyuan Lin, Changqi Yang, Yaosheng Chen, Zuyong He. Progress on SOX9 and its enhancers in mammalian sex determination[J]. Hereditas(Beijing), 2024, 46(9): 677-689.

Figures/Tables 5

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Progress on SOX9 and its enhancers in mammalian sex determination

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