增强子RNA研究现状

doi:10.16288/j.yczz.17-010

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Hereditas(Beijing) ›› 2017, Vol. 39 ›› Issue (9): 784-797.doi: 10.16288/j.yczz.17-010

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The current research status of enhancer RNAs

Xiao Cheng¹(),Qiong Yang²,Zhendong Tan¹,Ya Tan^1,⁴,Hongzhou Pu³,Xue Zhao¹,Shunhua Zhang¹(),Li Zhu¹()

¹ College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
² Department of Animal Husbandry and Veterinary Medicine, Chengdu Agricultural College, Chengdu 611305, China
³ Agricultural Bureau of Nanjiang Sichuan Province, Bazhong 635600, China
⁴ Animal Husbandry and Veterinary Institute of Guizhou Province, Guiyang 550005, China

Received:2017-01-11 Revised:2017-07-07 Online:2017-09-20 Published:2017-10-21
Supported by:
the Science and Technology Project of Sichuan Province(16ZC2838,2015NZ0013,2016NZ0089);the Technology Fumin County Special Action Plan Project of Sichuan Province and the Scientific Research Project of Sichuan Province Department of Education(16ZB0038)

Abstract

Abstract:

Enhancers are key cis-acting gene regulatory elements in eukaryotes, which can effectively promote the expression of target genes. Emerging evidence showed that enhancers in activation state could be transcribed to enhancer RNAs (eRNAs), the processes of which are regulated by various signaling systems and actions of signal-dependent transcription factors. Compared with the other transcripts (e.g. lncRNA, mRNA), eRNAs have shorter sequences, lower stability, and higher tissue specificity. eRNAs play roles in the initiation or stabilization of enhancer-promoter looping, and promote the expression of target genes. Recent studies have further showed that eRNAs have crucial roles in biological processes, such as development and disease initiation and progression. However, functional studies of eRNAs are currently lacking, and the regulatory mechanisms of eRNAs are still uncertain. Herein, we focus on the features, research methods and functional properties of eRNAs, and discusse the possibility of using eRNAs as therapeutic targets. We hope this discussion might provide some insights for further research on eRNAs.

Key words: enhancer RNAs (eRNAs), transcript, chromatin looping, functional characteristic

Xiao Cheng,Qiong Yang,Zhendong Tan,Ya Tan,Hongzhou Pu,Xue Zhao,Shunhua Zhang,Li Zhu. The current research status of enhancer RNAs[J]. Hereditas(Beijing), 2017, 39(9): 784-797.

References

[1]	Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang QB, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M. Genome-wide analysis of estrogen receptor binding sites. Nat Genet, 2006, 38(11): 1289-1297.
[2]	Spilianakis CG, Lalioti MD, Town T, Lee GR, Flavell RA. Interchromosomal associations between alternatively expressed loci. Nature, 2005, 435(7042): 637-645.
[3]	Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Science, 2005, 308(5725): 1149-1154.
[4]	Natoli G, Andrau JC. Noncoding transcription at enhancers: general principles and functional models. Annu Rev Genet, 2012, 46: 1-19.
[5]	Shlyueva D, Stampfel G, Stark A. Transcriptional enhancers: from properties to genome-wide predictions. Nat Rev Genet, 2014, 15(4): 272-286.
[6]	Banerji J, Rusconi S, Schaffner W. Expression of a β-globin gene is enhanced by remote SV40 DNA sequences. Cell, 1981, 27(2 pt 1): 299-308.
[7]	Gillies SD, Morrison SL, Oi VT, Tonegawa S. A tissue- specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell, 1983, 33(3): 717-728.
[8]	Banerji J, Olson L, Schaffner W. A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell, 1983, 33(3): 729-740.
[9]	Bulger M, Groudine M. Functional and mechanistic diversity of distal transcription enhancers. Cell, 2011, 144(3): 327-339.
[10]	Levine M. Transcriptional enhancers in animal development and evolution. Curr Biol, 2010, 20(17): R754-R763.
[11]	Blackwood EM, Kadonaga JT. Going the distance: a current view of enhancer action. Science, 1998, 281(5373): 60-63.
[12]	Buecker C, Wysocka J. Enhancers as information integration hubs in development: lessons from genomics. Trends Genet, 2012, 28(6): 276-284.
[13]	Xie W, Ren B. Developmental biology. Enhancing pluripotency and lineage specification. Science, 2013, 341(6143): 245-247.
[14]	Spitz F, Furlong EEM. Transcription factors: from enhancer binding to developmental control. Nat Rev Genet, 2012, 13(9): 613-626.
[15]	Calo E, Wysocka J. Modification of enhancer chromatin:

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