长链非编码RNA——抗病毒天然免疫应答的新兴调控因子

doi:10.16288/j.yczz.18-065

遗传 ›› 2018, Vol. 40 ›› Issue (7): 525-533.doi: 10.16288/j.yczz.18-065

长链非编码RNA——抗病毒天然免疫应答的新兴调控因子

张华伟^1,²,孟星宇¹,李连峰¹,杨玉莹²,仇华吉¹()

^1. 中国农业科学院哈尔滨兽医研究所,兽医生物技术国家重点实验室,哈尔滨 150069
^2. 长江大学动物科学学院,荆州 434023

收稿日期:2018-03-13 修回日期:2018-04-12 出版日期:2018-07-20 发布日期:2018-06-08
作者简介:张华伟,硕士研究生,专业方向：长链非编码RNA。E-mail:zhanghuaweirunner@163.com
基金资助:
国家自然科学基金项目资助(31700139)

Long non-coding RNAs: Emerging regulators of antiviral innate immune responses

Zhang Huawei^1,²,Meng Xingyu¹,Li Lianfeng¹,Yang Yuying²,Qiu Huaji¹()

^1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China
^2. College of Animal Sciences, Yangtze University, Jingzhou 434023, China

Received:2018-03-13 Revised:2018-04-12 Online:2018-07-20 Published:2018-06-08
Supported by:
Supported by the National Natural Science Foundation of China(31700139)

摘要/Abstract

摘要：

长链非编码RNA(long non-coding RNAs, lncRNAs)是长度超过200nt的非编码RNA分子的总称。作为一类重要的基因调控因子,lncRNAs在表观遗传学、转录及转录后等多个水平调控靶基因的表达。近年来的研究表明,许多lncRNAs可被病毒或干扰素(interferon, IFN)诱导表达,并作为调控因子在IFN介导的抗病毒天然免疫应答中调节抗病毒相关基因的表达。本文重点阐述了lncRNAs在IFN介导的抗病毒天然免疫应答中的调控作用,尤其是对干扰素刺激基因(interferon-stimulated genes, ISGs)转录的调控作用,并归纳了lncRNAs、IFN和ISGs形成的调控网络,以期为从事lncRNAs调控IFN介导的抗病毒天然免疫应答机制研究的相关科研人员提供参考。

关键词: 长链非编码RNA, 干扰素, 干扰素刺激基因, 抗病毒天然免疫应答

Abstract:

Long non-coding RNAs (lncRNAs) are designated as the transcripts longer than 200 nucleotides without protein-coding capacity. As a category of important gene regulatory factors, lncRNAs regulate the expression of target genes at epigenetic, transcription and post-transcriptional levels by various mechanisms, such as chromatin remodeling, DNA modification, transcription inhibition and RNA-RNA interactions, etc. In recent years, studies have shown that many lncRNAs can be induced by viruses or interferon (IFN) and to regulate the expression of related antiviral genes in IFN-mediated antiviral innate immune responses. In this review, we focus on the regulation of lncRNAs in IFN-mediated antiviral innate immune responses, especially in the transcription of IFN-stimulated genes (ISGs). In addition, we summarize the regulatory network of lncRNAs, IFN and ISGs. This review will provide a valuable reference for the researchers working in this field.

Key words: long non-coding RNAs, interferon, interferon-stimulated genes, antiviral innate immune response

张华伟, 孟星宇, 李连峰, 杨玉莹, 仇华吉. 长链非编码RNA——抗病毒天然免疫应答的新兴调控因子[J]. 遗传, 2018, 40(7): 525-533.

Zhang Huawei, Meng Xingyu, Li Lianfeng, Yang Yuying, Qiu Huaji. Long non-coding RNAs: Emerging regulators of antiviral innate immune responses[J]. Hereditas(Beijing), 2018, 40(7): 525-533.

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