[1] | Waddington CH . The epigenotype. Int J Epidemiol, 2011,41(1):10-13. | [2] | Allis CD, Jenuwein T . The molecular hallmarks of epigenetic control. Nat Rev Genet, 2016,17(8):487-500. | [3] | Dor Y, Cedar H . Principles of DNA methylation and their implications for biology and medicine. Lancet, 2018,392(10149):777-786. | [4] | Xiao CL, Zhu S, He M, Chen, Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, Wang DP, Bo XC, Gu XF, Wang K, Yan GR . N6-methyladenine DNA modification in the human genome. Mo Cell, 2018, 71(2): 306-318. e7. | [5] | Zhao BS, Roundtree IA, He C . Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Bio, 2016,18(1):31-42. | [6] | Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C, Chen J . FTO plays an oncogenic role in acute myeloid leukemia as a N 6-methyladenosine RNA demethylase . Cancer Cell, 2016,31(1):127-141. | [7] | Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, D. Riggs AD, He C, Shi Y . m 6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells . Cell Rep, 2017,18(11):2622-2634. | [8] | Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, He C, Huang S . m 6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell, 2017, 31(4): 591-606. e6. | [9] | Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL . Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5- mediated m 6A-demethylation of NANOG mRNA . Proc Natl Acad Sci USA, 2016,113(14):E2047-E2056. | [10] | Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J . Recognition of RNA N 6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation . Nat Cell Biol, 2018,20(3):285-295. | [11] | Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM . RNA N 6-methyladenosine methyltransferase- like 3 promotes liver cancer progression through YTHDF2- dependent posttranscriptional silencing of SOCS2 . Hepatology (Baltimore, Md), 2018,67(6):2254-2270. | [12] | Ma JZ, Yang F, Zhou CC, Liu F, Yuan JH, Wang F, Wang TT, Xu QG, Zhou WP, Sun SH . METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6-methyladenosine-dependent primary MicroRNA processing . Hepatology (Baltimore, Md), 2016,65(2):529-543. | [13] | Lawrence M, Daujat S, Schneider R . Lateral thinking: how histone modifications regulate gene expression. Trends Genet, 2015,32(1):42-56. | [14] | Zhang B, Zheng H, Huang B, Li W, Xiang Y, Peng X, Ming J, Wu X, Zhang Y, Xu Q, Liu W, Kou X, Zhao Y, He W, Li C, Chen B, Li Y, Wang Q, Ma J, Yin Q, Kee K, Meng A, Gao S, Xu F, Na J, Xie W . Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature, 2016,537(7621):553-557. | [15] | Benayoun B A, Pollina EA, Ucar D, Mahmoudi S, Karra K, Wong ED, Devarajan K, Daugherty AC, Kundaje AB, Mancini E, Hitz BC, Gupta R, Rando TA, Baker JC, Snyder MP, Cherry JM, Brunet A . H3K4me3 breadth is linked to cell identity and transcriptional consistency. Cell, 2014,158(3):673-688. | [16] | Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q, Li W . Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. Nat Genet, 2015,47(10):1149-1157. | [17] | Lai WKM, Pugh BF . Understanding nucleosome dynamics and their links to gene expression and DNA replication. Nat Rev Mol Cell Bio, 2017,18(9):548-562. | [18] | Nair SS, Kumar R . Chromatin remodeling in cancer: a gateway to regulate gene transcription. Mol Oncol, 2012,6(6):611-619. | [19] | Kadoch C, Crabtree GR . Mammalian SWI/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics. Science Advances, 2015,1(5):e1500447. | [20] | Sinha S, Boila LD, Chatterjee SS, Sengupta A. Chapter 2- miRNA and cancer:a deadly liaison. Academic Press, 2018, 27-46. | [21] | Pu M, Li C, Qi X, Chen J, Wang Y, Gao L, Miao L, Ren J . MiR-1254 suppresses HO-1 expression through seed region-dependent silencing and non-seed interaction with TFAP2A transcript to attenuate NSCLC growth. PLoS Genet, 2017,13(7):e1006896. | [22] | Zhao Y, Qi X, Chen J, Wei W, Yu C, Yan H, Pu M, Li Y, Miao L, Li C, Ren J . The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma. Cancer Lett, 2017,408:102-111. | [23] | Quinn JJ, Chang HY . Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet, 2016,17(1):47-62. | [24] | Chen LL . The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Bio, 2016,17(4):205-211. | [25] | Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y, Fan C, Li X, Li G, Li Y, Xiong W, Zeng Z . Circular RNAs (circRNAs) in cancer. Cancer Lett, 2018,425:134-142. | [26] | Zhang M, Zhao K, Xu X, Yang Y, Yan S, Wei P, Liu H, Xu J, Xiao F, Zhou H, Yang X, Huang N, Liu J, He K, Xie K, Zhang G, Huang S, Zhang N . A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun, 2018,9(1):4475. | [27] | Lauressergues D, Couzigou JM, Clemente HS, Martinez Y, Dunand C, Bécard G, Combier JP . Primary transcripts of microRNAs encode regulatory peptides. Nature, 2015,520(7545):90-93. | [28] | Anderson DM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN . A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell, 2015,160(4):595-606. | [29] | Nelson B, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, Reese AL, McAnally JR, Chen X, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN . A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science, 2016, 271-275. | [30] | Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, Laneve P, Rajewsky N, Bozzoni I . Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell, 2017, 66(1): 22-37. e9. | [31] | Huang JZ, Chen M, Chen D, Gao XC, Zhu S, Huang H, Hu M, Zhu H, Yan GR . A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth. Mol Cell, 2017, 68(1): 171-3184. e6. | [32] | Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, Huang S, Xie B, Zhang N . Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst Monographs, 2018,110(3). | [33] | Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, Li Z, Ming L, Xie B, Zhang N . A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene, 2018,37(13):1805-1814. | [34] | Li R, Liu Y, Hou Y, Gan J, Wu P, Li C . 3D genome and its disorganization in diseases. Cell Biol Toxicol, 2018,34(5):351-365. | [35] | Dixon J, Gorkin D, Ren B . Chromatin domains: the unit of chromosome organization. Mol Cell, 2016,62(5):668-680. | [36] | Tang Z, Luo OJ, Li X, Zheng M, Zhu JJ, Szalaj P, Trzaskoma P, Magalska A, Wlodarczyk J, Ruszczycki B, Michalski P, Piecuch E, Wang P, Wang D, Tian SZ, Penrad-Mobayed M, Sachs LM, Ruan X, Wei CL, Liu ET, Wilczynski GM, Plewczynski D, Li G, Ruan Y . CTCF-Mediated human 3D genome architecture reveals chromatin topology for transcription. Cell, 2015,163(7):1611-1627. | [37] | Rando OJ . Intergenerational transfer of epigenetic information in sperm. CSH Perspect Med, 2016,6(5):a022988. | [38] | Biswas S, Rao CM . Epigenetics in cancer: fundamentals and beyond. Pharmacol Ther, 2017,173:118-134. | [39] | Timp W, Bravo HC, McDonald OG, Goggins M, Umbricht C, Zeiger M, Feinberg AP, Irizarry RA . Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors. Genome Med, 2014,6(8):61. | [40] | Chalitchagorn K, Shuangshoti S, Hourpai N, Kongruttanachok N, Tangkijvanich P, Thong-ngam D, Voravud N, Sriuranpong V, Mutirangura A . Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene, 2004,23(54):8841-8846. | [41] | Shao C, Sun W, Tan M, Glazer CA, Bhan S, Zhong X, Fakhry C, Sharma R, Westra WH, Hoque MO, Moskaluk CA . Integrated, Genome-Wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma. Clin Cancer Res, 2011,17(13):4320-4330. | [42] | Neri F, Rapelli S, Krepelova A, Incarnato D, Parlato C, Basile G, Maldotti M, Anselmi F, Oliviero S . Intragenic DNA methylation prevents spurious transcription initiation. Nature, 2017,543(7643):72-77. | [43] | Visvanathan A, Patil V, Arora A, Hegde AS, Arivazhagan A, Santosh V, Somasundaram K . Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance. Oncogene, 2017,37(4):522-533. | [44] | Qiu Z, Wang J, Wu Y . The landscape of histone modification in cancer metastasis. 2018. | [45] | Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C, Wiedemann LM, Ge K, Krumlauf R, Shilatifard A . Global analysis of H3K4 methylation defines mll family member targets and points to a role for MLL1-Mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase Ⅱ. Mol Cell Biol, 2009,29(22):6074-6085. | [46] | Sun JM, Guo CC, Wang CQ, Cao K, Liu H, Han WC, Zheng MJ . Expression of BRG1 in colorectal cancer: correlation with prognosis and MMP-2 expression. World Chin J Digestol, 2016,24(35):4691-4699. | [46] | 孙晋敏, 郭存存, 王超群, 曹楷, 刘慧, 韩文灿, 郑茂金 . BRG1在结直肠癌中的表达与预后和MMP-2的关系. 世界华人消化杂志. 2016,24(35):4691-4699. | [47] | Tordella L, Khan S, Hohmeyer A, Banito A, Klotz S, Raguz S, Martin N, Dhamarlingam G, Carroll T, González Meljem JM, Deswal S, Martínez-Barbera JP, García- Escudero R, Zuber J, Zender L, Gil J . SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev, 2016,30(19):2187-2198. | [48] | Li X, Yao X, Wang Y, Hu F, Wang F, Jiang L, Liu Y, Wang D, Sun G, Zhao Y . MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features. PLoS One, 2013,8(3):e59064. | [49] | Lan F, Shi Y . Histone H3.3 and cancer: a potential reader connection. Proc Natl Acad Sci USA, 2014,112(22):6814-6819. | [50] | Lin CP, He L . Noncoding RNAs in cancer development. Annu Rev Cancer Biol, 2017,1(1):163-184. | [51] | Ivo D'Urso P, Fernando D’Urso O, Damiano Gianfreda C, Mezzolla V, Storelli C, Marsigliante S . MiR-15b and miR-21 as Circulating biomarkers for diagnosis of glioma. Curr Genomics, 2015,16(5):304-311. | [52] | Pardo OE, Castellano L, E Munro C, Hu Y, Mauri F, Krell J, Lara R, G Pinho F, Choudhury T, Frampton AE, Pellegrino L, Pshezhetskiy D, Wang Y, Waxman J, Seckl MJ, Stebbing J . MIR-515-5p controls cancer cell migration through MARK4 regulation. EMBO Rep, 2016,17(4):570-584. | [53] | Mei Q, Li X, Zhang K, Wu Z, Li X, Meng Y, Guo M, Luo G, Fu X, Han W . Genetic and methylation-induced loss of miR-181a2/181b2 within chr9q33.3 facilitates tumor growth of cervical cancer through PIK3R3/Akt/FoxO signaling pathway. Clin Cancer Res, 2017,23(2):575-586. | [54] | Zhao JL, Huang F, He F, Gao CC, Liang SQ, Ma PF, Dong GY, Han H, Qin HY . Forced activation of notch in macrophages represses tumor growth by upregulating miR-125a and disabling Tumor-Associated macrophages. Cancer Res, 2016,76(6):1403-1415. | [55] | Zhang Y, Hu J, Wang H, Cui J, Gao S, Hoffman AR, Li W . CRISPR Cas9-guided chromatin immunoprecipitation identifies miR483 as an epigenetic modulator of IGF2 imprinting in tumors. Oncotarget, 2016,8(21):34177-34190. | [56] | Yang L, Ma Y, Han W, Li W, Cui L, Zhao X, Tian Y, Zhou Z, Wang W, Wang H . Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation- mediated repression of MiR-125b. J Biol Chem, 2015,290(44):26627-26637. | [57] | Guo J, Lv J, Liu M, Tang H . MiR-346 Up-regulates argonaute 2 (AGO2) protein expression to augment the activity of other (MiRNAs) and contributes to cervical cancer cell malignancy. J Biol Chem, 2015,290(51):30342-30350. | [58] | Fang L, Cai J, Chen B, Wu S, Li R, Xu X, Yang Y, Guan H, Zhu X, Zhang L, Yuan J, Wu J, Li M . Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/β-catenin signalling. Nat Commun, 2015,6:8640. | [59] | Celià-Terrassa T, Liu DD, Choudhury A, Hang X, Wei Y, Zamalloa J, Alfaro-Aco R, Chakrabarti R, Jiang YZ, Koh BI, Smith HA, Decoste C, Li JJ, Zhao N, Kang Y . Normal and cancerous mammary stem cells evade interferon- induced constraint through the MIR-199a-LCOR axis. Nat Cell Biol, 2017,19(6):711-723. | [60] | Yang MH, Yu J, Chen N, Wang XY, Liu XY, Wang S, Ding YQ . Elevated MicroRNA-31 expression regulates colorectal cancer progression by repressing its target gene SATB2. PLoS One, 2013,8(12):e85353. | [61] | Fang J, Morsalin S, Rao VN, Shyam P. RE . Decoding of non-coding DNA and non-coding RNA: pri-micro RNA- encoded novel peptides regulate migration of cancer cells. J Pharm Sci Pharmacol 2017,3(1):23-27. | [62] | Shi J, Li Y, Fang XD . The mechanism and clinical significance of long noncoding RNA-mediated gene expression via nuclear architecture. Hereditas (Beijing), 2017,39(3):189-199. | [62] | 施剑, 李艳明, 方向东 . 长链非编码RNA通过细胞核高级结构调控真核基因表达及其临床意义. 遗传, 2017,39(3):189-199. | [63] | Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, Thomas M, Berdel WE, Serve H, Müller-Tidow C . MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene, 2003,22(39):8031-8041. | [64] | Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L . Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet, 2018,50(12):1705-1715. | [65] | Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z . The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of wnt signaling. Cell Stem Cell, 2015,16(4):413-425. | [66] | Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z . lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol, 2016,23(7):631-639. | [67] | Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z . LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun, 2016,7:13608. | [68] | Yuan Jh, Yang f, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, Wang SB, Wang YZ, Yang Y, Yang N, Zhou WP, Yang GS, Sun SH . A long noncoding RNA activated by TGF-β promotes the invasion- metastasis cascade in hepatocellular carcinoma. Cancer Cell, 2014,25(5):666-681. | [69] | Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, Li H, Zhan Q, Zhu Z . Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene, 2015,35(12):1575-1584. | [70] | Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, Zhou L, Qi X, Huang S, Hua D, Xing C, Huang Z . LncRNA - UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting MIR-204-5p. Sci Rep, 2016,6:23892. | [71] | Wu Y, Xiong Q, Li S, Yang X, Ge F . Integrated proteomic and transcriptomic analysis reveals long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) promotes hepatocellular carcinoma cell proliferation by regulating opioid growth factor receptor (OGFr). Mol Cell Proteomics, 2018,17(1):146-159. | [72] | Stojic L, Niemczyk M, Orjalo A, Ito Y, Ruijter AE, Uribe-Lewis S, Joseph N, Weston S, Menon S, T. Odom D, Rinn J, Gergely F, Murrell A . Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions. Nat Commun, 2016,7:10406. | [73] | Zheng J, Huang X, Tan W, Yu D, Du Z, Chang J, Wei L, Han Y, Wang C, Che X, Zhou Y, Miao X, Jiang G, Yu X, Yang X, Cao G, Zuo C, Li Z, Wang C, Cheung ST, Jia Y, Zheng X, Shen H, Wu C, Lin D . Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation. Nat Genet, 2016,48(7):747-757. | [74] | Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NMZ, Nagaraja AS, Gharpure KM, cGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK . MLong noncoding RNA ceruloplasmin promotes cancer growth by altering glycolysis. Cell Rep, 2015,13(11):2395-2402. | [75] | Yang H, Liu P, Zhang J, Peng X, Lu Z, Yu S, Meng Y, Tong WM, Chen J . Long noncoding RNA MIR31HG exhibits oncogenic property in pancreatic ductal adenocarcinoma and is negatively regulated by miR-193b. Oncogene, 2015,35(28):3647-3657. | [76] | Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L, Han S, Yuan Q, Yang M . MiRNA-192 and miRNA-204 directly suppress lncRNA HOTTIP and Interrupt GLS1-mediated glutamineolysis in hepatocellular carcinoma. PLoS Genet, 2015,11(12):e1005726. | [77] | Guarnerio J, Bezzi M, Jeong JC, Paffenholz SV, Berry K, Naldini MM, Lo-Coco F, Tay Y, Beck AH, Pandolfi PP . Oncogenic role of Fusion-circRNAs derived from cancer- associated chromosomal translocations. Cell, 2016,165(2):289-302. | [78] | Yang Q, Du WW, Wu N, Yang W, Awan FM, Fang L, Ma J, Li X, Zeng Y, Yang Z, Dong J, Khorshidi A, Yang BB . A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation. Cell Death Differ, 2017,24(9):1609-1620. | [79] | Li F, Zhang L, Li W, Deng J, Zheng J, An M, Lu J, Zhou Y . Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Oncotarget, 2015,6(8):6001-6013. | [80] | Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, Wang JJ . Circular RNA-ITCH suppresses lung cancer proliferation via inhibiting the Wnt/β-catenin pathway. Biomed Res Int, 2016,2016 1579490. | [81] | Huang G, Zhu H, Shi Y, Wu W, Cai H, Chen X . Cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLoS One, 2015,10(6):e0131225. | [82] | Guo W, Zhang J, Zhang D, Cao S, Li G, Zhang S, Wang Z, Wen P, Yang H, Shi X, Pan J, Ye H . Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma. Oncotarget, 2017,8(29):48169-48177. | [83] | Li CL, Nie H, Wang M, Su LP, Li JF, Yu YY, Yan M, Qu QL, Zhu ZG, Liu BY . MicroRNA-155 is downregulated in gastric cancer cells and involved in cell metastasis. Oncol Rep, 2012,27(6):1960-1966. | [84] | Barutcu AR, Lajoie BR, Mccord RP, Tye CE, Hong D, Messier TL, Browne G, van Wijnen AJ, Lian JB, Stein JL, Dekker J, Imbalzano AN, Stein GS . Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells. Genome Biol, 2015,16(1):214. | [85] | Taberlay PC, Achinger-kawecka J, Lun AT, Buske FA, Sabir K, Gould CM, Zotenko E, Bert SA, Giles KA, Bauer DC, Smyth GK, Stirzaker C . Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations. Genome Res, 2016,26(6):719-731. | [86] | Wu P, Li T, Li R, Jia L, Zhu P, Liu Y, Chen Q, Tang D, Yu Y, Li C . 3D genome of multiple myeloma reveals spatial genome disorganization associated with copy number variations. Nat Commun, 2017,8(1):1937. | [87] | Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, Suvà ML, Bernstein BE . Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature, 2015,529(7584):110-114. | [88] | Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, Goldmann J, Lajoie BR, Fan ZP, Sigova AA, Reddy J, Borges-Rivera D, Lee TI, Jaenisch R, Porteus MH, Dekker J, Young RA . Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science, 2016,351(6280):1454-1458. | [89] | Lin D, Hong P, Zhang S, Xu W, Jamal M, Yan K, Lei Y, Li L, Ruan Y, Fu ZF, Li G, Gao G . Digestion-ligation-only Hi-C is an efficient and cost-effective method for chromosome conformation capture. Nat Genet, 2018,50(5):754-763. | [90] | Sheng W, LaFleur MW, Nguyen TH, Chen S, Chakravarthy A, Conway JR, Li Y, Chen H, Yang H, Hsu PH, Van Allen EM, Freeman GJ, De Carvalho DD, He HH, Sharpe AH, Shi Y. , LSD1 ablation stimulates Anti-tumor immunity and enables checkpoint blockade. Cell 2018, 174(3): 549-563. e519. | [91] | Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RC, Wenzel A, Hicks J, Ballew M, Stone M, Tran PT, Zahnow CA, Hellmann MD, Anagnostou V, Strissel PL, Strick R, Velculescu VE, Baylin SB , . Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer. Cell 2017, 171(6):1284-1300. e21. | [92] | Li X, Su Y, Sun B, Ji W, Peng Z, Xu Y, Wu M, Su C . An artificially designed interfering lncRNA expressed by oncolytic adenovirus competitively consumes OncomiRs to exert antitumor efficacy in hepatocellular carcinoma. Mol Cancer Ther, 2016,15(7):1436-1451. | [93] | Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, Choi YJ, Sweeney KE, Suski JM, Yin H, Bogorad RL, Goel S, Yuzugullu H, Kauffman KJ, Yang J, Jin C, Li Y, Floris D, Swanson R, Ng K, Sicinska E, Anders L, Zhao JJ, Polyak K, Anderson DG, Li C, Sicinski P . Cell-Cycle-Targeting MicroRNAs as therapeutic tools against refractory cancers. Cancer Cell, 2017, 31(4): 576-590. e8. | [94] | Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BLL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V . Macrogenomic engineering via modulation of the scaling of chromatin packing density. Nat Biomed Eng, 2017,1(11):902-913. | [95] | Zhang WC, Wells JM, Chow KH, Huang H, Yuan M, Saxena T, Melnick MA, Politi K, Asara JM, Costa DB, Bult CJ, Slack FJ . MiR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma. Nat Metab, 2019,1(4):460-474. | [96] | Shen SY, Singhania R, Fehringer G, Chakravarthy A, Roehrl MHA, Chadwick D, Zuzarte PC, Borgida A, Wang TT, Li T, Kis O, Zhao Z, Spreafico A, Medina TDS, Wang Y, Roulois D, Ettayebi I, Chen Z, Chow S, Murphy T, Arruda A, O’Kane GM, Liu J, Mansour M, McPherson JD, O’Brien C, Leighl N, Bedard PL, Fleshner N, Liu G, Minden MD, Gallinger S, Goldenberg A, Pugh TJ, Hoffman MM, Bratman SV, Hung RJ, De Carvalho DD . Sensitive tumour detection and classification using plasma cell-free DNA methylomes. Nature, 2018,563(7732):579-583. | [97] | Legendre C, Gooden GC, Johnson K, Martinez RA, Liang WS, Salhia B . Whole-genome bisulfite sequencing of cell- free DNA identifies signature associated with metastatic breast cancer. Clin Epigenetics, 2015,7(1):100. | [98] | Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, Wu YM, Dhanasekaran SM, Engelke CG, Cao X, Robinson DR, Nesvizhskii AI, Chinnaiyan AM . The landscape of circular RNA in cancer. Cell, 2019, 176(4): 869-881. e13. |
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