癌症发生发展中的表观遗传学研究

doi:10.16288/j.yczz.19-077

遗传 ›› 2019, Vol. 41 ›› Issue (7): 567-581.doi: 10.16288/j.yczz.19-077

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癌症发生发展中的表观遗传学研究

张競文,续倩,李国亮()

华中农业大学信息学院,作物遗传改良国家重点实验室,农业生物信息学湖北省重点实验室,湖北省农业大数据工程技术研究中心,武汉 430070

收稿日期:2019-05-03 修回日期:2019-06-08 出版日期:2019-07-20 发布日期:2019-06-11
作者简介:张競文,博士研究生,专业方向：生物信息学。E-mail: 528260148@qq.com|续倩,硕士研究生,专业方向：生物信息学。E-mail: 1173405432@qq.com
基金资助:
国家自然科学基金项目(31771402);中央高校基本科研业务费专项资金资助项目资助(2662017PY116)

Epigenetics in the genesis and development of cancers

Jingwen Zhang,Qian Xu,Guoliang Li()

College of Informatics, National Key Laboratory of Crop Genetic Improvement, Agricultural Bioinformatics Key Laboratory of Hubei Province, Hubei Engineering Technology Research Center of Agricultural Big Data, Huazhong Agricultural University, Wuhan 430070, China

Received:2019-05-03 Revised:2019-06-08 Published:2019-07-20 Online:2019-06-11
Supported by:
Supported by the National Natural Science Foundation of China(31771402);Fundamental Research Funds for the Central Universities(2662017PY116)

摘要/Abstract

摘要：

癌症是由细胞恶性增殖和扩散引发的一类复杂疾病,解析其致病机制是人类目前面临的重大挑战之一。表观遗传学机制对维持基因特定的表达模式和生命个体的正常发育生长至关重要。表观遗传图谱的紊乱如组蛋白修饰、DNA/RNA甲基化和染色质三维构象的变化等均能在一定程度上干扰正常基因的表达和功能,进而诱导癌症等多种疾病的发生发展。为促进对表观遗传学在癌症中作用机制的理解,本文概述了表观遗传学研究内容,聚焦其与癌症发生发展之间的关联,同时展望了表观遗传学在癌症临床诊治中的应用。

关键词: 癌症, 表观遗传学, DNA/RNA甲基化, 组蛋白修饰, 核小体定位, 非编码RNA, 染色质三维结构

Abstract:

Cancer is a complex disease caused by the malignant cellular proliferation and metastasis. Elucidating its pathogenic mechanism is one of the major challenges that we face currently. Epigenetic mechanisms are essential for maintaining specific patterns of gene expression and normal development and growth of living individuals. Disorders of epigenetic markers, such as histone modification, DNA/RNA methylation, and changes in the three-dimensional conformation of chromatin, can interfere with gene expression to some extent, and result in cancers. This review provides a brief overview of epigenetics, focusing on their association with the genesis of cancers, and we look forward to the application of epigenetics in cancer clinical diagnosis and treatment.

Key words: cancers, epigenetics, DNA/RNA methylation, histone modification, nucleosome positioning, non-coding RNA, chromatin three-dimensional structure

张競文,续倩,李国亮. 癌症发生发展中的表观遗传学研究[J]. 遗传, 2019, 41(7): 567-581.

Jingwen Zhang,Qian Xu,Guoliang Li. Epigenetics in the genesis and development of cancers[J]. Hereditas(Beijing), 2019, 41(7): 567-581.

参考文献

[1]	Waddington CH . The epigenotype. Int J Epidemiol, 2011,41(1):10-13.
[2]	Allis CD, Jenuwein T . The molecular hallmarks of epigenetic control. Nat Rev Genet, 2016,17(8):487-500.
[3]	Dor Y, Cedar H . Principles of DNA methylation and their implications for biology and medicine. Lancet, 2018,392(10149):777-786.
[4]	Xiao CL, Zhu S, He M, Chen, Zhang Q, Chen Y, Yu G, Liu J, Xie SQ, Luo F, Liang Z, Wang DP, Bo XC, Gu XF, Wang K, Yan GR . N6-methyladenine DNA modification in the human genome. Mo Cell, 2018, 71(2): 306-318. e7.
[5]	Zhao BS, Roundtree IA, He C . Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Bio, 2016,18(1):31-42.
[6]	Li Z, Weng H, Su R, Weng X, Zuo Z, Li C, Huang H, Nachtergaele S, Dong L, Hu C, Qin X, Tang L, Wang Y, Hong GM, Huang H, Wang X, Chen P, Gurbuxani S, Arnovitz S, Li Y, Li S, Strong J, Neilly MB, Larson RA, Jiang X, Zhang P, Jin J, He C, Chen J . FTO plays an oncogenic role in acute myeloid leukemia as a N 6-methyladenosine RNA demethylase . Cancer Cell, 2016,31(1):127-141.
[7]	Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG, D. Riggs AD, He C, Shi Y . m 6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells . Cell Rep, 2017,18(11):2622-2634.
[8]	Zhang S, Zhao BS, Zhou A, Lin K, Zheng S, Lu Z, Chen Y, Sulman EP, Xie K, Bögler O, Majumder S, He C, Huang S . m 6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell, 2017, 31(4): 591-606. e6.
[9]	Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL . Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5- mediated m 6A-demethylation of NANOG mRNA . Proc Natl Acad Sci USA, 2016,113(14):E2047-E2056.
[10]	Huang H, Weng H, Sun W, Qin X, Shi H, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C, Yang J, Chen J . Recognition of RNA N 6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation . Nat Cell Biol, 2018,20(3):285-295.
[11]	Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM . RNA N 6-methyladenosine methyltransferase- like 3 promotes liver cancer progression through YTHDF2- dependent posttranscriptional silencing of SOCS2 . Hepatology (Baltimore, Md), 2018,67(6):2254-2270.
[12]	Ma JZ, Yang F, Zhou CC, Liu F, Yuan JH, Wang F, Wang TT, Xu QG, Zhou WP, Sun SH . METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6-methyladenosine-dependen

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癌症发生发展中的表观遗传学研究

Epigenetics in the genesis and development of cancers

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