遗传 ›› 2021, Vol. 43 ›› Issue (7): 642-653.doi: 10.16288/j.yczz.20-421

• 综述 • 上一篇    下一篇

NEK家族在细胞周期调控中的作用

李园园1(), 郭磊2, 韩之明1,3()   

  1. 1. 中国科学院动物研究所,干细胞与生殖生物学国家重点实验室,北京 100101
    2. 广东省第二人民医院生殖医学中心,生殖力保护实验室,广州 510317
    3. 北京干细胞与再生医学研究院,北京 100101
  • 收稿日期:2021-03-27 修回日期:2021-05-12 出版日期:2021-07-20 发布日期:2021-06-25
  • 通讯作者: 韩之明 E-mail:liyuanyuan891116@163.com;hanzm@ioz.ac.cn
  • 作者简介:李园园,博士,专业方向:发育生物学。E-mail: liyuanyuan891116@163.com
  • 基金资助:
    国家重点研发计划资助项目编号(2018YFC1004000);国家重点研发计划资助项目编号(2019YFA0109900);国家自然科学基金项目资助编号(31970509)

Roles of NEK family in cell cycle regulation

Li Yuanyuan1(), Guo Lei2, Han Zhiming1,3()   

  1. 1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    2. Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou 510317, China
    3. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China
  • Received:2021-03-27 Revised:2021-05-12 Online:2021-07-20 Published:2021-06-25
  • Contact: Han Zhiming E-mail:liyuanyuan891116@163.com;hanzm@ioz.ac.cn
  • Supported by:
    Supported by the National Key R&D Program of China Nos(2018YFC1004000);Supported by the National Key R&D Program of China Nos(2019YFA0109900);the National Natural Science Foundation of China No(31970509)

摘要:

NIMA相关激酶(NIMA-related kinases, NEKs)是丝氨酸/苏氨酸激酶,在细胞周期调控中发挥着重要的作用,参与了中心体分离、纺锤体组装、染色质凝集、核膜破裂、纺锤体组装检验点信号、胞质分裂、纤毛形成及DNA损伤反应等多种细胞活动。本文结合近年来在该激酶家族的相关研究,从NEK家族的组成、结构特征及其在有丝分裂和减数分裂过程中的作用等多个方面展开综述,以期为进一步研究NEKs在细胞周期调控中的作用提供重要基础,也为肿瘤的临床诊断和治疗提供理论依据。

关键词: NIMA相关激酶, 有丝分裂, 减数分裂

Abstract:

As a serine/threonine kinase, NIMA-related kinases (NEKs) play important roles in the regulation of cell cycle, and involve in several cellular activities such as centrosome separation, spindle assembly, chromatin condensation, nuclear envelope breakdown, spindle assembly checkpoint signaling, cytokinesis, cilia formation and DNA damage response. In this review, we summarize the component, structural characteristics and functions of NEK family in mitosis and meiosis based on the relevant researches in recent years, providing a reference for the further study on the roles of NEKs in the regulation of cell cycle and a theoretical basis for the clinical diagnosis and treatment of tumors.

Key words: NIMA-related kinases, mitosis, meiosis