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大型人群队列遗传资源建设与利用【专刊】

陈兴栋1,2 ,蒋艳峰1,2,徐萍3,4 ,金力1,2   

  1. 1. 复旦大学人类表型组研究院,遗传工程国家重点实验室,生命科学学院,上海 200433

    2. 复旦大学泰州健康科学研究院,泰州 225300

    3. 中国科学院上海生命科学信息中心,上海 200031

    4. 中国科学院上海营养与健康研究所,上海 200031

  • 收稿日期:2021-06-01 修回日期:2021-09-09 出版日期:2021-09-10 发布日期:2021-09-10
  • 通讯作者: 陈兴栋
  • 基金资助:
    国家重点研发计划项目;国家自然科学基金重大研究计划;上海市重大科技项目

Construction and utilization of genetic resources in large population cohorts

  • Received:2021-06-01 Revised:2021-09-09 Online:2021-09-10 Published:2021-09-10

摘要: 在大数据和精准医学的时代,大型人群队列研究是慢性病病因研究的首选设计之一,队列遗传资源已成为我国重要的战略资源。推动队列遗传资源的标准化建设与利用可有效促进生物医药领域研究与技术开发的原始创新。本文以“泰州队列”为例,介绍大型人群队列遗传资源建设过程中采集、保藏和共享利用的原则、方法、标准体系和具体实践经验等,以期为我国大型人群队列研究的遗传资源建设和利用提供参考与借鉴。

关键词: 大型人群队列, 遗传资源, 标准化, 共享利用

Abstract: In the era of big data and precision medicine, large population cohort studies are one of the preferred designs for studying the etiology of chronic diseases, and cohort genetic resources have become important strategic resources of China. Promoting the standardized construction and utilization of cohort genetic resources can effectively promote the original innovation of research and technological development in the field of biomedicine, and make full use of the rich genetic resources of China. To provide a reference for the construction and utilization of genetic resources in the cohort research in China, we took the Taizhou Longitudinal Study (TZL) as an example and introduced the principles, methods, standard system, and practical experience of the collection, preservation, and shared utilization of genetic resources in the process of the cohort construction.

Key words: large population cohort, genetic resource, standardization, shared utilization