遗传 ›› 2010, Vol. 32 ›› Issue (1): 41-48.doi: 10.3724/SP.J.1005.2010.00041

• 综述 • 上一篇    下一篇

组蛋白伴侣在发育过程中的功能

赵占克, 王玉凤   

  1. 华中师范大学生命科学学院, 遗传调控与整合生物学湖北省重点实验室, 武汉 430079
  • 收稿日期:2009-04-28 修回日期:2009-08-01 出版日期:2010-01-20 发布日期:2010-01-15
  • 通讯作者: 王玉凤 E-mail:yfengw@mail.ccnu.edu.cn
  • 基金资助:

    国家自然科学基金项目(编号:30671609)和淡水生态与生物技术国家重点实验室开放基金项目(编号:2005FB20)资助

The function of histone chaperones during development

ZHAO Zhan-Ke, WANG Yu-Feng   

  1. Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Science, Huazhong Normal University, Wuhan 430079,China
  • Received:2009-04-28 Revised:2009-08-01 Online:2010-01-20 Published:2010-01-15
  • Contact: WANG Yu-Feng E-mail:yfengw@mail.ccnu.edu.cn

摘要:

组蛋白伴侣能够协助组蛋白参与染色质的解凝和组装, 从而调控基因的表达, 对动植物的配子发生、受精、胚胎发育以及生长、衰老等发育过程都具有重要作用。文章主要对目前研究较多的组蛋白伴侣 — 核质蛋白、CAF-1、HIRA、ASF1/CIA及NAP1在发育过程中的相关功能作一综述。

关键词: 组蛋白伴侣, 核质蛋白, CAF-1, Hir/Hira, Asf1/CIA

Abstract:

Histone chaperones may participate the decondensation and assembly of chromatins, thus regulate gene expression. They play important roles in almost all developmental processes, such as gametogenesis, fertilization, embryogenesis, growth and senescence. In this review, we used well studied examples to illustrate various functions of histone chaperones during developmental processes. Focus is given to nucleoplasmin, CAF-1, HIRA, ASF1/CIA, and NAP1.

Key words: Asf1/CIA, Histonechaperones, Nucleoplasmin, CAF-1, Hir/Hira