遗传 ›› 2000, Vol. 22 ›› Issue (5): 293-294.

• 论文 • 上一篇    下一篇

p16蛋白在子宫内膜癌中表达的研究

郑冬梅1;武丽杰2;杨雪松1;李芳1;孙延芝1;陈黎明1;杨竹君2 ZHENG Dong-mei1;WU Li-jie2;YANG Xue-song1;LI Fang1;SUN Yan-zhi1;CHEN Li-ming1;YANG Zhu-jun2   

  1. 1.解放军211医院 优生优育中心,黑龙江哈尔滨 150086; 2.哈尔滨医科大学 公共卫生学院,黑龙江哈尔滨 150001 1.The Center of Healthy Birth of the 211 Hospital of PLA,Harbin 150086,China; 2.The Public Health College of Harbin Medical University,Harbin 150001,China
  • 收稿日期:1900-01-01 出版日期:2000-10-10 发布日期:2000-10-10

The Study on the Expression of P16 Gene in Carcinoma of Endometrium

  • Received:1900-01-01 Online:2000-10-10 Published:2000-10-10

摘要: 为探讨P16基因在子宫内膜癌发生及发展过程中所起的作用,采用免疫组化SP法对38例子宫内膜癌(腺癌33例,腺棘皮癌4例,浆液性乳头状腺癌1例)及19例正常组织进行了p16蛋白的免疫组化检测,结果p16蛋白在正常组织中表达率为56.8%,在腺癌中的表达率为21.7%,在腺棘皮和浆液性乳头腺癌中的表达率为25.1%,与正常组差异显著,同时,p16蛋白在Ⅰ-Ⅱ期子宫内膜中的表达率为26.4%。而在Ⅲ-Ⅳ期子宫内膜癌中的表达率为11.7% ,二者差异显著,说明p16蛋白在子宫内膜癌的发生及进展过程中起重要作用。
Abstract:To understand the role of P16 gene in the progression of carcinoma of endometrium,the expression of P16 gene was detected in 38 carcinoma of endometrium specimens and 19 controls by immunhistochemical SP method.The p16 protein positive rates of carcinoma of endometrium and control had significant difference (P<0.05),and the expression of p16 protein was also significant different between I~II grades and III~IV grades of adenocarcinoma of endometrium.So the p16 protein was closely associated with the generation and development of the carcinoma of endometrium.

关键词: 子宫内膜癌, p16蛋白, carcinoma of endometrium, p16 protein, 免疫组化SP法
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