遗传 ›› 2003, Vol. 25 ›› Issue (2): 137-140.

• 论文 • 上一篇    下一篇

北京地区汉族妇女雌激素受体基因XbaI多态性与骨密度和体重指数的关系

薛延1;李东2;王芊1;董兆文2   

  1. 1.北京积水潭医院创伤骨科研究所,北京 100035;2.国家计划生育委员会科学技术研究所分子生物学研究室,北京 1000811.
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-04-10 发布日期:2003-04-10

XbaI Polymorphisms of the Estrogen Receptor Gene and Bone Mineral Density and BMI in Beijing Han Women

XUE Yan1;LI Dong2;WANG Qian1;DONG Zhao-Wen2   

  1. Institute of Traumatology and Orthopaedics,Beijing Jishuitan Hospital,Beijing 100035,China;2.National Research Institute for Family Planing,Beijing 100081,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2003-04-10 Published:2003-04-10

摘要: 为探讨北京地区汉族妇女雌激素受体(ER)基因XbaI多态性与骨密度的关系,采用双能X线吸收仪检测腰椎、股骨及前臂骨密度;采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法,对179例北京地区汉族妇女ER基因XbaI多态性进行分析。北京地区汉族妇女ER基因XX、Xx和xx基因型频率分布为0.302、0.464和0.234,绝经前与绝经后妇女XbaI型基因频率分布有明显差异,绝经后妇女腰椎骨密度(0.836±0.18)g/cm2明显低于绝经前妇女(1.038±0.14);绝经后妇女骨质疏松症的发病率为54%。ER基因XbaI基因型频率分布有明显的种族差异并受绝经影响,ER基因XbaI基因型与骨密度无明显相关性。与体重和BMI有明显相关性。

关键词: 骨密度, 体重指数, XbaI基因型, 雌激素受体

Abstract: The work is to study the relationship between XbaI polymorphisms of the estrogen receptor(ER) gene and bone mineral density in Beijing Han women.Bone mineral density(BMD) was measured at lumbar spine,proximal femoral and arm by dual energy X-ray absorptionetry(DEXA) and ER gene was determined by polymerase Chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 179 Beijing Han women.The frequency of the ER genotype of XX、Xx and xx was 0.302,0.464 and 0.234 in Beijing Han women.There was a signficant difference between premenopausal and postmenopausal women in the frequency of the XbaI genotype.The BMD of lumbar spine in postmenopausal women(0.836±0.18g/cm2)was significally lower than that in premenopausal women (1.038±0.14g/cm2)(P<0.01) and the incidence of osteoporosis in postmenopausal women was 54.3%.The frequency of XbaI genotype of ER gene in Han women.There was apparently different from that in other races in and menopause effected on the frequency of XbaI genotype.The XbaI genotype of ER gene was nonassociated with BMD.and significantly associated with BMI.