遗传 ›› 2004, Vol. 26 ›› Issue (2): 227-230.

• 论文 • 上一篇    下一篇

心肌细胞形成和分化过程中钙信号转导调控得研究进展

王跃群;刘明耀;吴秀山WANG Yue-Qun;LIU Ming-Yao;WU Xiu-Shan   

  1. 心肌; 形成; 分化; 钙离子; 信号转导Key words: cardiomyocyte; cardiomyogenesis; differentiation; calcium; signaling pathways
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-03-28 发布日期:2004-03-28

Progress of the Calcium Signal Pathway During Cardiomyogenesis and Cardiomyocyte Differentiation

  • Received:1900-01-01 Revised:1900-01-01 Online:2004-03-28 Published:2004-03-28

摘要: 脊椎动物心肌细胞形成和分化是胚胎细胞一系列特定基因的精确转录表达过程,细胞内Ca2+信号转导系统在此起着重要的作用。该文对Ca2+依赖性转录过程:Ca2+ /CaM/CaN /NFAT /GATA4转录信号途径和Ca2+/CaM/CaMK/HDAC/MEF2转录信号途径指导下的心肌细胞的形成与分化研究进展作一综述。 Abstract: The process of cardiomyogenesis and cardiomyocyte differentiation in vertebrates is complex,which is controlled by a series of cardiac embryonic genes.The underlying calcium signaling pathways are important to the expression of these genes.The role of calciumdependent transcription process,Ca2+/CaM/CaN/NFAT/GATA4 transcription pathway and Ca2+/CaM/ CaMK/HDAC/MEF2 transcription pathway,in cardiomyogenesis and cardiomyocyte differentiation are reviewed.

关键词: 湖南师范大学生命科学学院发育生物学及蛋白质化学教育部重点实验室心脏发育研究中心, 湖南 长沙 410081College of Life Sciences, Hunan 410081, Hunan Normal University, Changsha, China