遗传 ›› 2005, Vol. 27 ›› Issue (4): 636-640.

• 专论与综述 • 上一篇    下一篇

ADAM33基因研究进展

苏智广; 文富强; 冯玉麟   

  1. 四川大学华西医院呼吸病学研究室, 成都 610041
  • 收稿日期:2004-03-18 修回日期:2004-11-30 出版日期:2005-08-10 发布日期:2005-08-10
  • 通讯作者: 苏智广

Progress in Study of ADAM33 Gene

SU Zhi-Guang, WEN Fu-Qiang, FENG Yu-Lin   

  1. Laboratory of Pulmonary Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
  • Received:2004-03-18 Revised:2004-11-30 Online:2005-08-10 Published:2005-08-10
  • Contact: SU Zhi-Guang

摘要: ADAM33基因定位于20号染色体短臂20p13,属于ADAM基因超家族。ADAM基因超家族编码的蛋白质具有金属蛋白酶活性,这种活性与多种疾病的发生相关。在不同人群中的病例-对照及家系研究提示ADAM33基因可作为哮喘的候选基因,其抑制剂有望用于哮喘病的治疗。

关键词: ADAM基因家族, ADAM33基因, 哮喘

Abstract: A disintegin and metalloprotease (ADAM ) 33, located on the short arm of chromosome 20 (20p13), was recently identified through a genome-wide scan for asthma. It is a new member of a family of genes encoding a group of the metalloproteinase superfamily called the ADAM family. The proteolytic activity of the ADAMs plays important role in the healthy and disease states. The identification of ADAM33 as a candidate gene for asthma may provide a newly therapeutic target for asthma.