人类免疫缺陷病毒初始传播病毒的鉴别及其表型特征

doi:10.16288/j.yczz.14-452

遗传 ›› 2015, Vol. 37 ›› Issue (5): 419-425.doi: 10.16288/j.yczz.14-452

人类免疫缺陷病毒初始传播病毒的鉴别及其表型特征

赵建元^1,2,丁寄葳²,米泽云²,魏涛¹,岑山²

1. 北京联合大学应用文理学院,北京 100192;
2. 中国医学科学院/北京协和医学院医药生物技术研究所,北京 100050

收稿日期:2014-12-19 出版日期:2015-05-20 发布日期:2015-05-20
通讯作者: 岑山,博士,研究员,研究方向：病毒学。E-mail: shancen@hotmail.com;魏涛,硕士,教授,研究方向：病毒学。E-mail: weitao@buu.edu.cn
作者简介:作者简介:赵建元,硕士研究生,专业方向：病毒学。E-mail: Zjyuan815@163.com
基金资助:
北京联合大学研究生创新基金(编号：12246994501)和国家基金委-加拿大国立卫生研究院研究基金课题(CIHR)合作基金(编号：81361128017)资助

Identification and characterization of HIV-1 transmitted /founder viruses

Jianyuan Zhao^{1, 2}, Jiwei Ding², Zeyun Mi², Tao Wei¹, Shan Cen²

1. Department of Food Science, College of Arts & Science of Beijing Union University, Beijing 100192, China;
2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical School, Beijing 100050, China

Received:2014-12-19 Online:2015-05-20 Published:2015-05-20

摘要/Abstract

摘要： 人类免疫缺陷病毒(Human immunodeficiency virus type 1, HIV-1)简称艾滋病病毒,在粘膜传播过程中,病毒的遗传多样性是显著减少的。绝大多数的HIV-1粘膜感染由一个或者少数几个病毒建立并最终发展为系统感染,上述病毒称为初始传播病毒(Transmitted/founder virus, T/F virus)。通过对初始传播病毒表型特征的研究,可进一步了解病毒在新宿主体内成功复制的关键特性,为艾滋病疫苗的发展、暴露前预防及其他治疗性干预措施提供更好的策略。文章综述了初始传播病毒的发现、进化特征以及感染后初期宿主的免疫反应等,以期为深入研究初始传播病毒的特征提供理论基础。

关键词: 人类获得性免疫缺损病毒, 病毒传播, 急性感染期, 初始传播病毒

Abstract: During the spread of human immunodeficiency virus type 1 (HIV-1) in the mucosa, the entire genetic diversity of the viruses is significantly reduced. The vast majority of HIV-1 mucosal infections are established by one or a few viruses and ultimately develop into systemic infections, thus the initial virus is called transmitted/founder virus (T/F virus). The study of T/F virus will benefit understanding its key characteristics resulting in successful viral replication in the new host body, which may provide novel strategies for the development of AIDS vaccines, pre-exposure prophylaxis and other therapeutic interventions. In this review, we summarize the discovery and evolutionary characteristics of T/F virus as well as early immune response after HIV-1 infection, which will establish the basis to explore the features of T/F viruses.

Key words: human immunodeficiency virus type 1(HIV-1), viral transmission, acute infection, transmitted /founder virues (T/F Virus)

赵建元,丁寄葳,米泽云,魏涛,岑山. 人类免疫缺陷病毒初始传播病毒的鉴别及其表型特征[J]. 遗传, 2015, 37(5): 419-425.

Jianyuan Zhao, Jiwei Ding, Zeyun Mi, Tao Wei, Shan Cen. Identification and characterization of HIV-1 transmitted /founder viruses[J]. HEREDITAS(Beijing), 2015, 37(5): 419-425.

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