遗传 ›› 2017, Vol. 39 ›› Issue (11): 1066-1077.doi: 10.16288/j.yczz.17-121

• 综述 • 上一篇    下一篇

PPARγ在脂肪生成中的遗传和表观遗传调控

崔婷婷1,2,3(),邢天宇1,2,3,褚衍凯1,2,3,李辉1,2,3,王宁1,2,3()   

  1. 1. 农业部鸡遗传育种重点实验室,哈尔滨 150030
    2. 黑龙江省普通高等学校动物遗传育种与繁殖重点实验室,哈尔滨 150030
    3. 黑龙江省动物细胞与遗传工程重点实验室,哈尔滨 150030
  • 收稿日期:2017-03-30 修回日期:2017-06-29 出版日期:2017-11-20 发布日期:2017-12-20
  • 作者简介:崔婷婷,在读博士,助理研究员,专业方向：动物遗传育种与繁殖。E-mail: cuitingting.1985@163.com|王宁，博士，教授，研究方向：动物遗传育种与繁殖。E-mail: wangning@neau.edu.cn
  • 基金资助:
    国家自然科学基金项目(31572392,31372299);农业部产业体系项目(CARS-42)

Genetic and epigenetic regulation of PPARγ during adipogenesis

Tingting Cui1,2,3(),Tianyu Xing1,2,3,Yankan Chu1,2,3,Hui Li1,2,3,Ning Wang1,2,3()   

  1. 1. Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, Harbin 150030, China
    2. Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, Harbin 150030, China
    3. Key Laboratory of Animal Cells and Genetic Engineering of Heilongjiang Province, Harbin 150030, China
  • Received:2017-03-30 Revised:2017-06-29 Online:2017-11-20 Published:2017-12-20
  • Supported by:
    the National Natural Science Foundation of China(31572392,31372299);the China Agriculture Research System(CARS-42)

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摘要：

过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor gamma, PPARγ)是脂肪生成和脂肪组织发育的关键调控因子,另外在糖脂代谢、炎症和免疫反应等多种生物学过程中也发挥重要作用。近年来,对PPARγ基因的研究一直是脂肪生物学研究的热点。随着研究的不断深入,人们发现PPARγ基因不仅受遗传调控,还受DNA甲基化、组蛋白修饰、非编码RNA和染色质重塑等表观遗传调控。本文综述了PPARγ基因在脂肪生成中的遗传和表观遗传调控研究进展,探讨了未来PPARγ基因调控的研究方向和趋势。

关键词: PPARγ, 脂肪生成, 遗传调控, 表观遗传调控, 基因表达

Abstract:

Peroxisome proliferator-activated receptor gamma (PPARγ) is the master regulator of adipogenesis and adipose tissue development. It also plays crucial roles in many other biological processes, including lipid and glucose metabolism and energy homeostasis. Recently, evidence has been accumulating that the PPARγ gene is not only genetically regulated, but also epigenetically regulated by DNA methylation, histone modification, non-coding RNA and chromosome remodeling. In this review, we summarize the advances in the genetic and epigenetic regulation of the PPARγ gene during adipogenesis, and discuss future research directions and trends for the study of its regulation.

Key words: PPARγ, adipogenesis, genetic regulation, epigenetic regulation, gene expression