中国丝状真菌次级代谢分子调控研究进展

doi:10.16288/j.yczz.18-169

遗传 ›› 2018, Vol. 40 ›› Issue (10): 874-887.doi: 10.16288/j.yczz.18-169

中国丝状真菌次级代谢分子调控研究进展

潘园园¹(),刘钢^1,²()

^1. 中国科学院微生物研究所,真菌学国家重点实验室,北京100101
^2. 中国科学院大学,北京 100049

收稿日期:2018-06-22 修回日期:2018-08-23 出版日期:2018-10-20 发布日期:2018-09-10
作者简介:潘园园,助理研究员,研究方向：丝状真菌次级代谢的分子调控。E-mail: panyy@im.ac.cn
基金资助:
国家自然科学基金项目(31470177);国家自然科学基金项目(31770056)

Research advances on molecular regulation of filamentous fungal secondary metabolism in China

Yuanyuan Pan¹(),Gang Liu^1,²()

^1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
^2. University of Chinese Academy of Sciences, Beijing 100049, China

Received:2018-06-22 Revised:2018-08-23 Online:2018-10-20 Published:2018-09-10
Supported by:
the National Natural Science Foundation of China(31470177);the National Natural Science Foundation of China(31770056)

摘要/Abstract

摘要：

在目前已知的具有生物活性的微生物次级代谢物中约有50%是由丝状真菌产生的,其中包括人们所熟知的青霉素、环孢菌素A以及洛伐他汀等。鉴于丝状真菌次级代谢物在农业、医药和工业上的重要价值,它们的生物合成及其分子调控一直备受关注。丝状真菌次级代谢物的生物合成是一个复杂的过程,一般涉及多步酶学反应,该过程往往受到不同水平的调控。深入了解丝状真菌次级代谢的分子调控机制,可以为其产量的提高、新骨架化合物的发掘以及隐性次级代谢物的激活奠定重要的理论基础。本文以丝状真菌次级代谢分子调控为主线,重点介绍近40年来我国科研工作者在该领域取得的研究进展,并对这一领域未来的发展进行展望。

关键词: 中国, 丝状真菌, 分子调控, 次级代谢

Abstract:

More than half of the activity secondary metabolites from microorganisms are produced by filamentous fungi. The metabolites that are well known include penicillin, cyclosporine A, lovastatin, and so on. Due to their importance in agriculture, medicine and industry, biosynthesis and regulation of these fungal secondary metabolites have attracted much attention. The biosynthesis of fungal secondary metabolites is a complex process which generally includes multistep enzymatic reactions. Commonly, the process is controlled by elaborate regulations at different levels. A good understanding of the molecular regulation of fungal secondary metabolism will lay a theoretical foundation for improving metabolite production, mining novel compounds and activating the silent gene clusters. In this review, we focus on molecular regulation of filamentous fungal secondary metabolite biosynthesis, especially the research advances of Chinese scientists in recent forty years are mainlyintroduced. Finally, we propose the future challenges and opportunities in this field.

Key words: China, filamentous fungi, molecular regulation, secondary metabolism

潘园园, 刘钢. 中国丝状真菌次级代谢分子调控研究进展[J]. 遗传, 2018, 40(10): 874-887.

Yuanyuan Pan, Gang Liu. Research advances on molecular regulation of filamentous fungal secondary metabolism in China[J]. Hereditas(Beijing), 2018, 40(10): 874-887.

参考文献

[1]	Bok JW, Keller NP . LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot Cell, 2004,3(2):527-535.
[2]	Wang YP, Tan YM, Zhou GQ, Lan Y, Liu YX, Luo Z, Liu ZY . Recent advances of global regulator LaeA of filamentous fungi. Genomics and Applied Biology, 2017,36(2):712-718.
[2]	王亚萍, 谭玉梅, 周国庆, 兰亚, 刘永翔, 罗钊, 刘作易 . 丝状真菌全局性调控因子LaeA的研究进展. 基因组学与应用生物学, 2017,36(2):712-718.
[3]	Bok JW, Balajee SA, Marr KA, Andes D, Nielsen KF, Frisvad JC, Keller NP . LaeA, a regulator of morphogenetic fungal virulence factors. Eukaryot Cell, 2005,4(9):1574-1582.
[4]	Jiang T, Wang M, Li L, Si J, Song B, Zhou C, Yu M, Wang X, Zhang Y, Ding G, Zou Z . Overexpression of the global regulator LaeA in Chaetomium globosum leads to the biosynthesis of Chaetoglobosin Z. J Nat Prod, 2016,79(10):2487-2494.
[5]	Zheng Y, Cao S, Huang Y, Liao G, Hu C . Overexpression of LaeA enhances mevastatin production and reduces sporulation of Penicillium citrinum. Acta Microbiol Sin, 2014,54(12):1438-1445.
[6]	Zhou F . The research of the proteins interacting with the global regulator, LaeA in the Pennicillium citrinum. [Dissertation]. Southwest University, 2014.
[6]	周峰 . 橘青霉全局性调控因子LaeA相互作用蛋白研究 [学位论文]. 西南大学, 2014.
[7]	Zhang X, Zhu Y, Bao L, Gao L, Yao G, Li Y, Yang Z, Li Z, Zhong Y, Li F, Yin H, Qu Y, Qin Y . Putative methyltransferase LaeA and transcription factor CreA are necessary for proper asexual development and controlling secondary metabolic gene cluster expression. Fungal Genet Biol, 2016,94:32-46.
[8]	Liu Q, Cai L, Shao Y, Zhou Y, Li M, Wang X, Chen F . Inactivation of the global regulator LaeA in Monascus ruber results in a species-dependent response in sporulation and secondary metabolism. Fungal Biol, 2016,120(3):297-305.
[9]	Lv YY . Study on regulation of secondary metabolism in Aspergillus niger FGSC A1279 [Dissertation]. South China University of Technology, 2014.
[9]	吕扬勇 . 黑曲霉FGSC A1279次级代谢调控研究[学位论文]. 华南理工大学, 2014.
[10]	Wang B, Lv YY, Li XJ, Lin YY, Deng H, Pan L . Profiling of secondary metabolite gene clusters regulated by LaeA in Aspergillus niger FGSC A1279 based on genome sequencing and transcriptome analysis. Res Microbiol, 2018,169(2):67-77.
[11]	Akhberdi O, Zhang Q, Wang D, Wang H, Hao X, Liu Y, Wei D, Zhu X . Distinct roles of velvet complex in the development, stress tolerance, and secondary metabolism in Pestalotiopsis microspora, a taxol producer. Genes, 2018,9(3):164. doi: 10.3390/genes9030164.
[12]
[1]	王雪倩, 张庆珍, 程鹏, 董婷婷, 李卫国, 周喆, 王升启. 中国汉族人群66个InDel基因座的遗传多态性[J]. 遗传, 2022, 44(4): 335-345.
[2]	李茜, 王浩宇, 曹悦岩, 朱强, 舒潘寅, 侯婷芸, 王雨婷, 张霁. 微单倍型遗传标记的法医基因组学研究[J]. 遗传, 2021, 43(10): 962-971.
[3]	刘志勇, 任贺, 陈冲, 张京晶, 张晓梦, 石妍, 石林玉, 陈滢, 程凤, 贾莉, 陈曼, 范庆炜, 张家榕, 李万婷, 王萌春, 任子林, 刘雅诚, 倪铭, 孙宏钰, 严江伟. 基于有限突变模型和大规模数据的19个常染色体STR的实际突变率研究[J]. 遗传, 2021, 43(10): 949-961.
[4]	王文秀, 黄涛, 李立明. 基于“中国慢性病前瞻性研究”的遗传资源建设与应用[J]. 遗传, 2021, 43(10): 972-979.
[5]	刘明, 李祎, 杨亚芳, 晏于文, 刘凡, 李彩霞, 曾发明, 赵雯婷. 中国汉族人群脸部特征相关SNP位点研究[J]. 遗传, 2020, 42(7): 680-690.
[6]	刘杨, 孙昌春, 马咪, 王玲, 赵雯婷, 马泉, 季安全, 刘京, 李彩霞. 74-plex SNPs复合检测体系在中国人群中的族群推断研究[J]. 遗传, 2020, 42(3): 296-308.
[7]	刘莉莉, 郭爱伟, 吴培福, 陈粉粉, 杨亚晋, 张勤. 敲降VPS28基因对中国荷斯坦奶牛乳脂合成的调控[J]. 遗传, 2018, 40(12): 1092-1100.
[8]	宋述慧,滕徐菲,肖景发. 中国人群参考基因组及基因组变异图谱资源库[J]. 遗传, 2018, 40(11): 1048-1054.
[9]	陈德富,卢大儒,张飞雄,张根发. 中国遗传学教学40年发展及展望[J]. 遗传, 2018, 40(10): 916-923.
[10]	李红花,刘钢. CRISPR/Cas9在丝状真菌基因组编辑中的应用[J]. 遗传, 2017, 39(5): 355-367.
[11]	杨湛澄, 黄河天, 闫青霞, 王雅春, 俞英, 陈绍祜, 孙东晓, 张胜利, 张毅. 利用高密度SNP标记分析中国荷斯坦牛基因组近交[J]. 遗传, 2017, 39(1): 16-23.
[12]	谢建平, 韩玉波, 刘钢, 白林泉. 2015年中国微生物遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(9): 765-790.
[13]	张博, 陈晓芳, 黄勋, 杨晓. 2015年中国动物遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(6): 467-507.
[14]	李元丰, 韩玉波, 曹鹏博, 孟金凤, 李海北, 秦庚, 张锋, 靳光付, 杨勇, 邬玲仟, 平杰, 周钢桥. 2015年中国医学遗传学研究领域若干重要进展[J]. 遗传, 2016, 38(5): 363-390.
[15]	陈涛，王小蓉，罗华，王春涛，张家志，罗明敏. 9个野生中国樱桃群体叶绿体DNA trnQ-rps16序列变异及其遗传结构分析[J]. 遗传, 2012, 34(11): 1475-1483.

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

中国丝状真菌次级代谢分子调控研究进展

Research advances on molecular regulation of filamentous fungal secondary metabolism in China

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

编辑推荐

Metrics