LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

doi:10.16288/j.yczz.17-358

遗传 ›› 2018, Vol. 40 ›› Issue (4): 292-304.doi: 10.16288/j.yczz.17-358

LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

周瑞,王以鑫,龙科任,蒋岸岸,金龙()

四川农业大学,畜禽遗传资源发掘与创新利用四川省重点实验室,成都 611130

收稿日期:2017-12-18 修回日期:2018-03-01 出版日期:2018-04-20 发布日期:2018-03-19
作者简介:周瑞,硕士研究生,专业方向：动物遗传育种与繁殖。E-mail: 948417369@qq.com
基金资助:
国家自然科学基金项目(31601919);国家自然科学基金项目(31772576);国家自然科学基金项目(31522055);四川省教育厅项目(16ZB0037);四川省省院省校科技合作研发项目(2017JZ0025);四川省青年科技创新研究团队资助(2015TD0012)

Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals

Rui Zhou,Yixin Wang,Keren Long,Anan Jiang,Long Jin()

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China

Received:2017-12-18 Revised:2018-03-01 Published:2018-04-20 Online:2018-03-19
Supported by:
Supported by the National Natural Science Foundation of China(31601919);Supported by the National Natural Science Foundation of China(31772576);Supported by the National Natural Science Foundation of China(31522055);the Project of Sichuan Education Department(16ZB0037);the Project of Sichuan Provincial and Municipal Science and Technology Cooperation in Research and Development(2017JZ0025);Sichuan Youth Science and Technology Innovation Research Team(2015TD0012)

摘要/Abstract

摘要：

骨骼肌是维持机体功能必不可少的组织,与家养动物的产肉率等重要经济性状密切相关。近年来,高通量测序鉴定了大量与骨骼肌生成相关的长链非编码RNA (long non-coding RNA, lncRNA),它们可作为调节因子在表观调控、转录调控以及转录后调控等多个层面调控基因表达。lncRNA通过靶向关键因子参与调控骨骼肌发育的各个环节,包括骨骼肌干细胞增殖、迁移、分化,成肌细胞增殖、分化、肌管融合,肌纤维肥大和纤维类型转换等过程。本文重点归纳了lncRNA在人和小鼠骨骼肌发育中的分子调控机制,介绍了lncRNA的研究方法,综述了lncRNA在家养动物骨骼肌发育中的研究进展,分析了目前家养动物lncRNA研究所面临的困难和挑战,最后展望了未来家养动物lncRNA研究的方向,以期为进一步阐明骨骼肌生长发育的分子调控机制提供参考。

关键词: 长链非编码RNA, 骨骼肌, 作用机制, 发育, 家养动物

Abstract:

Skeletal muscle is an essential tissue to maintain the normal functions of an organism. It is also closely associated with important economic performance, such as carcass weight, of domestic animals. In recent years, studies using high-throughput sequencing techniques have identified numerous long non-coding RNAs (lncRNAs) with myogenic functions involved in regulation of gene expression at multiple levels, including epigenetic, transcriptional and post-transcriptional regulation. These lncRNAs target myogenic factors, which participate in all processes of skeletal muscle development, including proliferation, migration and differentiation of skeletal muscle stem cells, proliferation, differentiation and fusion of myocytes, muscle hypertrophy and conversion of muscle fiber types. In this review, we summarize the functional roles of lncRNAs in regulation of myogenesis in humans and mice, describe the methods for the analysis of lncRNA function, discuss the progress of lncRNA research in domestic animals, and highlight the current problems and challenges in lncRNA research on livestock production. We hope to provide a useful reference for research on lncRNA in domestic animals, thereby further identifying the molecular regulatory mechanisms in skeletal muscle growth and development.

Key words: long non-coding RNAs, skeletal muscle, acting mechanism, development, domestic animals

周瑞,王以鑫,龙科任,蒋岸岸,金龙. LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展[J]. 遗传, 2018, 40(4): 292-304.

Rui Zhou,Yixin Wang,Keren Long,Anan Jiang,Long Jin. Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals[J]. Hereditas(Beijing), 2018, 40(4): 292-304.

参考文献

[1]	Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest ARR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E , Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SPT, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CAM, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group). The transcriptional landscape of the mammalian genome. Science, 2005,309(5740):1559-1563.
[2]	Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu FF, Reese AL , McAnally JR, Chen XW, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science, 2016,351(6270):271-275.
[3]	Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR , McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN. A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell, 2015,160(4):595-606.
[4]	Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R , Olson EN. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. Sci Signal, 2016, 9(457): ra119.
[5]	Quan MY, Chen JH, Zhang DQ . Exploring the secrets of long noncoding RNAs. Int J Mol Sci, 2015,16(3):5467-5496.
[6]	Li YY, Chen XN, Sun H, Wang HT . Long non-coding RNAs in the regulation of skeletal myogenesis and muscle diseases. Cancer Lett, 2

编辑推荐

Metrics

www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:

LncRNA调控骨骼肌发育的分子机制及其在家养动物中的研究进展

Regulatory mechanism for lncRNAs in skeletal muscle development and progress on its research in domestic animals

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics