遗传 ›› 2021, Vol. 43 ›› Issue (4): 375-384.doi: 10.16288/j.yczz.21-005

• 资源与平台 • 上一篇    

MDMPR:小鼠发育代谢表型库

朱文静, 刘志玮()   

  1. 苏州大学,剑桥-苏大基因组资源中心,苏州 215123
  • 收稿日期:2021-01-05 修回日期:2021-03-04 出版日期:2021-04-20 发布日期:2021-04-20
  • 通讯作者: 刘志玮 E-mail:liuzhiwei@cam-su.org
  • 作者简介:朱文静,硕士,实验技术员,研究方向:生物化学与分子生物学。E-mail: zhuwenjing@cam-su.org
  • 基金资助:
    科技部重点研发计划项目资助编号(2018YFA0801100)

MDMPR: Mouse Developmental and Metabolic Phenotype Repository

Wenjing Zhu, Zhiwei Liu()   

  1. Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China
  • Received:2021-01-05 Revised:2021-03-04 Online:2021-04-20 Published:2021-04-20
  • Contact: Liu Zhiwei E-mail:liuzhiwei@cam-su.org
  • Supported by:
    Supported by the National Key R&D Program of the Ministry of Science and Technology of China No(2018YFA0801100)

摘要:

小鼠发育代谢表型库(Mouse Developmental and Metabolic Phenotype Repository, MDMPR)是一个致力于小鼠资源和表型数据实时共享的开放性平台,它依托于科技部重点研发计划“发育编程及其代谢调节”专项项目“建立小鼠发育代谢表型库”。该项目预计在5年内完成500个发育代谢相关小鼠敲除模型的建立,并对其表型数据进行标准化的解析、建立表型数据库。MDMPR作为一个资源及数据集成的库,由多个子系统作为支撑,包括ES细胞数据库、项目管理系统、繁育管理系统、精子库管理系统、表型分析系统,信息化管理深入到项目中每个环节,从基因突变ES细胞制备、基因突变小鼠制备、小鼠繁育,精子冻存到最终的表型分析、数据处理及展示,保证了MDMPR产生数据的真实性及实时性。MDMPR除了不断地推进项目进行,增加自身产生的数据外,也在积极的整合其他的资源及数据,如人特异性基因敲除ES细胞库、蛋白相互作用数据库(STRING)、核心转录调节环路(dbCoRc)和Enhancer-Indel数据库,今后还将进一步整合,帮助发育代谢及其他领域的研究人员能够一站式的获取所需资源和数据、加快研究进程,最终服务于全人类的医疗事业。

关键词: 小鼠发育代谢表型库, 资源库, 开放共享平台

Abstract:

Mouse Developmental and Metabolic Phenotype Repository (MDMPR) is an open access, real-time database which dedicates to share mouse resources and phenotype data. MDMPR is supported by the National Key Research and Development Project “Establishment of Mouse Developmental and Metabolic Phenotype Repository” within the Key Project of “Developmental Programming and Its Metabolic Regulation” from the Ministry of Science and Technology of the People’s Republic of China’s program. In the next 5 years, MDMPR will create 500 mutant mouse models related to development and metabolism, perform standard phenotyping analysis, and establish a phenotype database. MDMPR is a combination of resources and data repository, has several sub-systems, including the ES cell database, the project management system, the breeding management system, the sperm bank management system and the phenotyping database. These systems digitalize all data and ensure their authenticity in real-time. Besides the gradual increase of data during the project, MDMPR will also integrate other resources, such as human KO ES cell database, STRING database, database of Core Transcriptional Regulatory Circuitries and Enhancer-Indel database. MDMPR is anticipated to contribute to various areas of developmental and metabolic research to investigators through more convenient accesses to the resources and data in one-stop manner, thereby accelerating the research processes and ultimately serving the medical causes of human health.

Key words: Mouse Development and Metabolic Phenotype Repository, resource repository, open-access sharing platform