遗传 ›› 2023, Vol. 45 ›› Issue (11): 976-985.doi: 10.16288/j.yczz.23-173

• 综述 • 上一篇    下一篇

甲型流感病毒宿主适应的分子基础及其相关宿主因子的研究进展

孙婷婷(), 岑山(), 王静()   

  1. 中国医学科学院医药生物技术研究所,北京协和医学院医药生物技术研究所,北京 100050
  • 收稿日期:2023-06-26 修回日期:2023-08-25 出版日期:2023-11-20 发布日期:2023-09-20
  • 通讯作者: 岑山,王静 E-mail:1165852674@qq.com;jingwang@imb.pumc.edu.cn;shancen@imb.pumc.edu.cn
  • 作者简介:孙婷婷,硕士研究生,专业方向:微生物与生化药学。E-mail: 1165852674@qq.com
  • 基金资助:
    国家自然科学基金面上项目(81971950);中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-038)

Progress on viral and host determinants of influenza A virus species specificity

Tingting Sun(), Shan Cen(), Jing Wang()   

  1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100050,China
  • Received:2023-06-26 Revised:2023-08-25 Published:2023-11-20 Online:2023-09-20
  • Contact: Shan Cen,Jing Wang E-mail:1165852674@qq.com;jingwang@imb.pumc.edu.cn;shancen@imb.pumc.edu.cn
  • Supported by:
    the National Natural Science Foundation of China(81971950);CAMS Innovation Fund for Medical Sciences(2021-I2M-1-038)

摘要:

甲型流感病毒宿主广泛,传染性强,可引起人畜共患病,严重威胁人类健康和公共卫生安全。甲型流感病毒可以通过基因突变和基因重配等机制不断变异,如果新毒株打破宿主限制获得在人类传播的能力,有可能造成流感大流行。理解流感病毒突破种间屏障的遗传学基础和分子机制,是科学界亟待解决的问题,对有效监控和预防潜在流感大爆发的具有重要的提示作用。本文对目前研究流感病毒宿主适应的分子决定因素展开了综述,着重介绍了病毒本身的遗传变异以及和病毒相互作用的宿主因子的作用,以便为应对下次流感大流行做好理论储备,为抵抗流感寻找新策略。

关键词: 甲型流感病毒, 跨种传播, 宿主适应, 分子基础

Abstract:

Influenza A viruses have a wide range of hosts and are highly infectious, which can cause zoonotic diseases and pose a serious public health threat to human safety. An influenza pandemic could outbreak if new strains gain the ability of human-to-human transmission, either by genetic mutation or by gene reassortment. It is an urgent issue for the scientific community to reveal the genetic basis and molecular mechanisms underlying the interspecies transmission of influenza viruses, which will provide important implications for the effective monitoring and prevention of potential influenza pandemics. In this review, we summarize the molecular determinants of influenza viruses for host adaptation, and highlight the advances in the gene mutations of the virus itself and the interaction between virus and host factors. This will help to make a theoretical reserve for the next influenza pandemic and find new strategies to fight against influenza.

Key words: influenza A virus, interspecies transmission, host adaptation, molecular basis