嗅觉受体基因的研究进展

doi:10.3724/SP.J.1005.2010.00017

遗传 ›› 2010, Vol. 32 ›› Issue (1): 17-24.doi: 10.3724/SP.J.1005.2010.00017

嗅觉受体基因的研究进展

高一龙^{1, 2}, 缪勤¹, 张汇东¹, 温海¹, 秦海斌¹, 谢庄²

1. 公安部南京警犬研究所, 南京 210012; 2. 南京农业大学动物科技学院, 南京 210095

收稿日期:2009-05-06 修回日期:2009-07-29 出版日期:2010-01-20 发布日期:2010-01-15
通讯作者: 谢庄 E-mail:zxie@ njau.edu.cn

Advances on olfactory receptor gene

GAO Yi-Long^{1, 2}, MIU Qin¹, ZHANG Hui-Dong¹, WEN Hai¹, QIN Hai-Bin¹, XIE Zhuang²

1. Nanjing Policedog Institute of the Ministry of Public Security, Nanjing 210012, China; 2. College of Animal Science and Technology, Nanjing Agriculture University, Nanjing 210095, China

Received:2009-05-06 Revised:2009-07-29 Online:2010-01-20 Published:2010-01-15
Contact: XIE Zhuang E-mail:zxie@ njau.edu.cn

摘要/Abstract

摘要：

嗅觉在动物的生命活动中起着重要的作用, 与嗅觉相关的基因主要是嗅觉受体(Olfactory receptor, OR)基因。文章介绍了嗅觉受体基因的结构、表达调控、分布、分子进化及其多态性研究进展, 并讨论了该基因与嗅觉功能和嗅觉障碍的关系。

关键词: 多态性, 嗅觉功能, 嗅觉受体基因；痕量胺相关的受体基因；多态性；嗅觉功能；嗅觉障碍痕量胺相关的受体基因, 嗅觉障碍

Abstract:

The olfactory sense plays a key role in animals’life time. The main gene related with olfaction was olfactory receptor (OR) gene. This review introduced the structure, expression regulation, distribution, molecular evolution and polymorphism of OR gene. The relationship between OR gene and olfactory function and olfactory deficits was also dis-cussed

Key words: olfactory deficitsTrace Amine Associated Receptors, polymorphism, olfactory receptor gene；Trace Amine-Associated Receptors gene, polymorphism；olfactory function

高一龙，缪勤，张汇东，温海，秦海斌，谢庄. 嗅觉受体基因的研究进展[J]. 遗传, 2010, 32(1): 17-24.

GAO Yi-Long, JIU Qi, ZHANG Hui-Dong, WEN Hai, QIN Hai-Bin, XIE Peng. Advances on olfactory receptor gene[J]. HEREDITAS, 2010, 32(1): 17-24.

参考文献

[1] Malakoff D. Following the scent of avian olfaction. Science, 1999, 286(5440): 704-705.

[2] Stoddart DM. The Ecology of Vertebrate Olfaction. Lon-don, Chapman and Hall, 1980, 208-226.

[3] Buck L, Axel R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 1991, 65(1): 175-187.

[4] Sharon D, Glusman G, Pilpel Y, Horn-Saban S, Lancet D. Genome dynamics, evolution, and protein modeling in the olfactory receptor gene superfamily. Ann N Y Acad Sci, 1998, 855: 182-193.

[5] Niimura Y, Nei M. Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates. J Hum Genet, 2006, 51(6): 505-517.

[6] Niimura Y, Nei M. Extensive gains and losses of olfactory receptor genes in mammalian evolution. PLoS ONE, 2007, 2(8): e708.

[7] Glusman G,Yanai L,Rubin L, Lancet D.The complete human olfactory subgenome.Genome Res, 2001, 11(5): 685-702.

[8] Olender T, Fuchs T,Linhart C, Shamir R, Adams M, Kalush F, Khen M, Lancet D.The canine olfactory subge-nome. Genomics, 2004, 83(3): 361-372.

[9] Zhang X, Firestein S. The olfactory receptor gene super-family of the mouse. Nat Neurosci, 2002, 5(2): 124-133.

[10] Mombaerts P. Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci, 2004, 5(4): 263-278.

[11] Gaillard I, Rouquier S, Chavanieu A, Mollard P, Giorgi D. Amino-acid changes acquired during evolution by olfac-tory receptor 912-93 modify the specificity of odorant recognition. Hum Mol Genet, 2004, 13(7): 771-780.

[12] Floriano WB, Vaidehi N, Goddard III WA. Making sense of olfaction through predictions of the 3-D structure and function of olfactory receptors. Chem Senses, 2004, 29(4): 269-290.

[13] Young JM, Trask BJ. The sense of smell: genomics of vertebrate odorant receptors. Hum Mol Genet, 2002, 11(10): 1153-1160.

[14] Tacher S, Quignon P, Rimbault M, Dreano S, Andre C, Galibert F. Olfactory receptor sequence polymorphism within and between breeds of dogs. J Hered, 2005, 96(7): 812-816.

[15] Niimura Y, Nei M. Evolution of olfactory receptor genes in the human genome. Proc Natl Acad Sci USA, 2003, 100: 12235-12240.

[16] Godfrey PA, Malnic B, Buck LB. The mouse olfactory receptor gene family. Proc Natl Acad Sci USA, 2004, 101: 2156-2161.

[17] Quignon P, Kirkness E, Cadieu E, Touleimat N, Guyon R, Renier C, Hitte C, André C, Fraser C, Galibert F. Com-parison of the canine and human olfactory receptor gene repertoires. Genome Biol, 2003, 4(12): R80

[18] Freitag J, Krieger J, Strotmann J, Breer H. Two classes of olfactory receptors in Xenopus laevis. Neuron, 1995, 15(6): 1383-1392.

[19] Niimura Y, Nei M. Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proc Natl Acad Sci USA, 2005, 102: 6039-6044.

[20] Freitag J, Ludwig G, Andreini I, Rössler P, Breer H. Ol-factory receptors in aquatic and terrestrial vertebrates. J Comp Physiol, 1998, 183(5): 635-650.

[21] Malnic B, Godfrey PA, Buck L B. The human olfactory receptor gene family. Proc Natl Acad Sci USA, 2004, 101: 7205-7205.

[22] Vassar R, Ngai J, Axel R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithe-lium. Cell, 1993, 74(2): 309-318.

[23] Vassar R, Chao SK, Sitcheran R, Nuñez JM, Vosshall LB, Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell, 1994, 79(6): 981-991.

[24] Firestein S. How the olfactory system makes sense of scents. Nature, 2001, 413(6852): 211-218.

[25] Asai H, Kasal H, Matsuda Y, Yamazaki N, Nagawa F, Sakano H, Tsuboi A. Genomic structure and transcription of a murine odorant rec

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嗅觉受体基因的研究进展

Advances on olfactory receptor gene

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