精神分裂症相关单核苷酸多态性调控microRNA功能研究进展

doi:10.16288/j.yczz.19-126

遗传 ›› 2019, Vol. 41 ›› Issue (8): 677-685.doi: 10.16288/j.yczz.19-126

精神分裂症相关单核苷酸多态性调控microRNA功能研究进展

梁文权¹,侯豫²,赵存友¹()

^1. 南方医科大学基础医学院医学遗传学教研室,广州 510515
^2. 陆军总医院附属八一儿童医院神经发育科,北京 100700

收稿日期:2019-05-08 修回日期:2019-07-07 出版日期:2019-08-20 发布日期:2019-08-05
通讯作者: 赵存友 E-mail:cyzhao@smu.edu.cn
作者简介:梁文权,硕士在读研究生,专业方向：表观遗传。E-mail:wen1390229749@163.com
基金资助:
广东省科技计划项目(2019B030316032);广州市科技计划项目(201804010259);国家自然科学基金项目资助(81601175);国家自然科学基金项目资助(81671333)

Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function

Liang Wenquan¹,Hou Yu²,Zhao Cunyou¹()

^1. Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
^2. Department of Pediatric Neurology, Affiliated BaYi Children's Hospital, PLA Army General Hospital, Beijing 100700, China

Received:2019-05-08 Revised:2019-07-07 Online:2019-08-20 Published:2019-08-05
Contact: Zhao Cunyou E-mail:cyzhao@smu.edu.cn
Supported by:
Supported by the Guangdong Science and Technology Foundation(2019B030316032);The Guangzhou Science and Technology Foundatio(201804010259);The National Natural Science Foundation of China(81601175);The National Natural Science Foundation of China(81671333)

摘要/Abstract

摘要：

MicroRNA (miRNAs)是一类长约22nt且对基因表达具有广泛的调控作用的非编码RNA,并在神经元增殖、分化和发育成熟的过程中扮演重要角色。近年来全基因组关联研究(genome-wide association studies, GWAS)发现了众多的精神分裂症相关单核苷酸多态性(single nucleotide polymorphisms, SNPs)位点多位于非编码区,表明miRNA在精神分裂症的发病过程中存在重要作用。本文综述了精神分裂症相关SNP与miRNA可能发生相互作用的4种机制(SNP位于miRNA基因、SNP位于miRNA宿主基因、SNP位于miRNA种子序列和SNP位于miRNA结合位点),为研究miRNA在精神分裂症发生发展中的作用提供参考。

关键词: 全基因组关联研究, 单核苷酸多态性, 微小RNA, 精神分裂症

Abstract:

MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA’s seed sequence; SNP located in the miRNA’s binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.

Key words: GWAS, SNP, miRNA, schizophrenia

梁文权,侯豫,赵存友. 精神分裂症相关单核苷酸多态性调控microRNA功能研究进展[J]. 遗传, 2019, 41(8): 677-685.

Liang Wenquan,Hou Yu,Zhao Cunyou. Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function[J]. Hereditas(Beijing), 2019, 41(8): 677-685.

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