遗传 ›› 2011, Vol. 33 ›› Issue (7): 695-706.doi: 10.3724/SP.J.1005.2011.00695

• 综述 • 上一篇    下一篇

动物季节性繁殖分子调控机理研究进展

黄冬维, 储明星   

  1. 中国农业科学院北京畜牧兽医研究所, 农业部畜禽遗传资源与利用重点开放实验室, 北京 100193
  • 收稿日期:2010-11-06 修回日期:2011-02-18 出版日期:2011-07-20 发布日期:2011-07-25
  • 通讯作者: 储明星 E-mail:mxchu@263.net
  • 基金资助:

    国家现代农业产业技术体系建设专项资金(编号:CARS-39), 国家863计划(编号:2006AA10Z139), 国家973计划(编号:2006CB102105), 国家科技支撑计划(编号:2008BADB2B01), 国家自然科学基金项目(编号:30300248和30871773)和中国农业科学院首批优秀科技创新团队专项资助

Research progress in molecular mechanism of animal seasonal reproduction

HUANG Dong-Wei, CHU Ming-Xing   

  1. Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
  • Received:2010-11-06 Revised:2011-02-18 Online:2011-07-20 Published:2011-07-25

摘要: 动物季节性发情繁殖涉及下丘脑-垂体-性腺轴系统复杂的神经内分泌过程, 并受光照周期等环境因素的影响。褪黑激素则作为光周期信号分子调控动物季节性繁殖活动。近年来研究发现, 对GnRH分泌有重要影响的Kiss1/GPR54系统既受褪黑激素的调控又受到性腺类固醇激素反馈调节, Kiss1/GPR54系统很可能是调控动物季节性繁殖的关键因子; 同时动物季节性繁殖很可能还存在一条涉及TSH-DIO2/DIO3系统的逆向调控通路, 该系统同样显著影响GnRH合成释放并受褪黑激素调控。文章就褪黑激素中心信号, 特别是Kiss1/GPR54和TSH-DIO2/DIO3系统对繁殖季节性调控的最新研究进展进行综述。

关键词: 分子调控, 褪黑激素, Kiss1, 促甲状腺素, 季节性繁殖

Abstract: Animal seasonal reproduction involves complicated neuroendocrine processes of the hypothalamo-pituitary-gonadal axis. It is dominantly regulated by photoperiod, a crucial environmental cue. Melatonin, as internal photoperiod signal, regulates seasonal reproduction of animals. In recent years, it has been found that Kiss1/GPR54 system, which may influence GnRH secretion evidently, is regulated by both melatonin and feedback action of gonadal steroid hormones. Consequently, Kiss1/GPR54 system may play a key role in seasonal reproduction. Additionally, there exists another potential retrograde control pathway of seasonal breeding, which involves TSH-DIO2/DIO3 system. TSH-DIO2/ DIO3 system affects synthesis and secretion of GnRH and is regulated by melatonin, as well as Kiss1/GPR54 system. In this article, melatonin signal, especially the research advances of Kiss1/GPR54 system and TSH-DIO2/DIO3 system were reviewed.

Key words: seasonal reproduction, molecular regulation, melatonin, Kiss1, thyroid-stimulating hormone