[1] Edson MA, Lin YN, Matzuk MM. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology, 2010, 151(1): 358-368.[2] Goldman RD. Drug-induced gynecomastia in children and adolescents. Can Fam Physician, 2010, 56(4): 344-345.[3] Islam SK, Hossain KJ, Kamal M, Ahsan M. Serum immunoglobulins and white blood cells status of drug addicts: influence of illicit drugs and sex habit. Addict Biol, 2004, 9(1): 27-33.[4] Tanaka S, Shaikh IM, Chiocca EA, Saeki Y. The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One, 2009, 4(6): e5922.[5] Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science, 2009, 323(5916): 946-951.[6] Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C. GPR3 receptor, a novel actor in the emotional-like responses. PLoS One, 2009, 4(3): e4704.[7] Ruiz-Medina J, Ledent C, Valverde O. GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. Neuropharmacology, 2011, 61(1-2): 43-50.[8] Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA. The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science, 2004, 306(5703): 1947-1950.[9] Ledent C, Demeestere I, Blum D, Petermans J, Hämäläinen T, Smits G, Vassart G. Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci USA, 2005, 102(25): 8922-8926.[10] Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T. Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett, 1993, 336(2): 317-322.[11] Iismaa TP, Kiefer J, Liu ML, Baker E, Sutherland GR, Shine J. Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. Genomics, 1994, 24(2): 391-394.[12] Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem J, 1995, 309(Pt 3): 837-843.[13] Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science, 1989, 244(4904): 569-572.[14] Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marçais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL. A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol, 2009, 10(4): R42.[15] Zhang BL, Ding JH, Li Y, Wang JJ, Zhao YY, Wang W, Shi S, Dong FL, Zhang ZJ, Shi FX, Xu YX. The porcine Gpr3 gene: molecular cloning, characterization and expression level in tissues and cumulus-oocyte complexes during in vitro maturation. Mol Biol Rep, 2012, 39(5): 5831-5839.[16] Rovati GE, Capra V, Neubig RR. The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Mol Pharmacol, 2007, 71(4): 959-964.[17] Aizaki Y, Maruyama K, Nakano-Tetsuka M, Saito Y. Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control. Peptides, 2009, 30(5): 974-981.[18] Song ZH, Modi W, Bonner TI. Molecular cloning and chromosomal localization of human genes enco |