遗传 ›› 1991, Vol. 18 ›› Issue (3): 200-207.

• 论文 • 上一篇    下一篇

α-珠蛋白-3′HVR探针DNA指纹图法医应用的研究

李伯龄;倪锦堂;叶 健;丁 焰;储晓兰   

  1. 公安部型事技术研究所,100038
  • 收稿日期:1900-01-01 修回日期:1900-01-01

The Application of α-globin-3′HVR Probe for DNA Fingerprinting in Forensic Sci ence

Li Boling, Ni Jintang, Ye Jian, Ding Yan, Chu Xiaolan   

  1. Institute of Forensic Science,Ministry of Public Security,Beijing 100038
  • Received:1900-01-01 Revised:1900-01-01

摘要: α-珠蛋白-3′HVR探针所建立的杂我方法,获得清晰可辩的DNA指纹图。就北京载我200名无 关个体的DNA指纹图分析和统计结果,其相关机率为4.0×10 -12,对6个家系的32名相关个 体的分析,符合孟德尔定律,足以用作准确的个人识别和亲子关系鉴定,并已用于检案,为 侦破强奸、凶杀等案件提供了重要依据。

关键词: 亲子鉴定, 相关机率, 个人识别, DNA指纹图, α-珠蛋白-3′HVR探针, α-珠蛋白-3′HVR探针, DNA指纹图, 相关机率, 亲子鉴定, 个人识别

Abstract: Using α-globin-3′HVR as the molecular hybridization probe,A clear and readable DNA fingerprint has been obtained.Based on the DNA fingerprint analysis of 200 unrelated individuals living in Beijing area,the probability of chance associati on of two random individuals was 4.0×10 -12. The study of 32 related individuals of 6 families showed that the inheritanc e of DNA fingerprint bands conformed to the Mendelian law.The method is reliable for the individual identification and paternity test.It provides a scientific b asis for solving cases such as rape,homicide etc.and it has been used in our act ual case work.

Key words: Paternity test, α-globin-3′HVR probe, DNA fingerprint, Probability of chance association.Individ ual identificafion